C&MP 550a: Physiological Systems
- Cellular and Molecular Physiology: C&MP 550a
- Biomedical Engineering: BENG 350a
- Engineering and Applied Science: ENAS 550a
- Molecular and Cellular Developmental Biology: MCDB 310a/550a
Classes: MWF 9:25-10:15 am
Location: 211 Mason Laboratory
Format: 36 Lectures, weekly quizzes, two midterm examinations, final examination.
Discussion Sections: Students will be assigned to one discussion section M 7-8pm; M 8-9pm; T 7-8pm; or T 8-9pm.
Additional weekly meeting for graduate students:
Wednesdays with Instructor in SHM B-145 at 5 to 6pm.
Lead Instructor: Mark Saltzman, Ph.D.
Graduate Student Conference Leader: Emile Boulpaep, M.D.
|Peter S. Aronson, M.D.||TAC Sfirstname.lastname@example.org|
|Emile Boulpaep, M.D.||SHM Bemail@example.com|
|Michael Caplan, M.D., Ph.D.||SHM B116firstname.lastname@example.org|
|Elizabeth Holt, M.D., Ph.D.||LLCI email@example.com|
|Michael Nitabach, Ph.D., J.D.||SHM BE firstname.lastname@example.org|
Mark Saltzman, Ph.D
Teaching Fellows & Discussion Section Leaders:
The course develops a foundation in human physiology by examining the homeostasis of vital parameters within the body, and the biophysical properties of cells, tissues, and organs. Basic concepts in cell and membrane physiology are synthesized through exploring the function of skeletal, smooth, and cardiac muscle. The physical basis of blood flow, mechanisms of vascular exchange cardiac performance and regulation of overall circulatory function are discussed. Respiratory physiology explores the mechanics of ventilation, gas diffusion, and acid-base balance. Renal physiology examines the formation and composition of urine and the regulation of electrolyte, fluid, and acid-base balance. Organs of the digestive system are discussed from the perspective of substrate metabolism and energy balance. Hormonal regulation is applied to metabolic control and to calcium, water, and electrolyte balance. The biology of nerve cells is addressed with emphasis on synaptic transmission and simple neuronal circuits within the central nervous system. The special senses are considered in the framework of sensory transduction. Weekly discussion sections provide a forum for in-depth exploration of topics. Graduate students evaluate research findings through literature review and weekly meetings with the instructor.
Nature and amount of work required
Text (BENG 350a, MCDB 310a): Berne and Levy "Physiology", Koeppen and Stanton , 2008 6th edition
Text (ENAS 550a, MCDB 550a, CMP 550a):Textbook of Medical Physiology (2002) by Walter Boron and Emile Boulpaep, W.B. Saunders Company
Number of pages of reading per week: ~ 50 to 70; indicated for each lecture.
Quizzes and Discussion Sections: (20% of grade)
Midterm: Two midterms (each 20% of grade).
End of term: Final examination (40% of grade).
Examination format: multiple choice, true-false, & short answer.
Graduate students: weekly meeting and report (20% of grade).
Fall 2008 Schedule
W Sep 3
Homeostasis: levels of organization, body systems, feedback.
B: 3-6; 9-49
F Sep 5
Plasma Membrane: Organization & Signalling.
B: 9-49 & 50-54; & 87-113
M Sep 8
Membrane Transport: Potentials, Fluxes, and Active Transport
W Sep 10
Electrophysiology of Cell Membranes
B: 145 - 154
F Sep 12
Neuronal Physiology & Nerve Conduction
M Sep 15
Synaptic Transmission Neuromuscular Junction
W Sep 17
Skeletal Muscle: organization, excitation & contraction, mechanics.
Muscle Properties: fiber types, feedback, smooth & cardiac.
F Sep 19
Organization of the Cardiovascular System
M Sep 22
Arteries, Veins, Microcirculation and Lymphatics.
W Sep 24
F Sep 26
The Heart as a Pump
M Sep 29
Control of Blood Pressure, Cardiac Output and Venous Return.
W Oct 1
Overview and Mechanics of Respiration
F Oct 3
Membrane Function, Excitability, and Cardiovascular Physiology
M Oct 6
W Oct 8
Carriage and diffusion of oxygen and carbon dioxide
F Oct 10
Ventilation-Perfusion and Acid-Base Balance
M Oct 13
Control of Respiration
W Oct 15
Organization of the Urinary System.
Renal clearance; Reabsorption and Secretion
F Oct 17
Glomerular Filtration and Renal Blood Flow
M Oct 20
Renal Handling of Na and Cl
W Oct 22
Urine Concentration and Dilution
F Oct 24
Renal Mechanisms of Acid-Base Balance
M Oct 27
Integrative Renal Function
W Oct 29
Digestion: Pancreas, Liver, Intestines
B: 947-967, Portions of Ch.42, 45
F Oct 31
Digestive Tract and Regulation
M Nov 3
Pituitary/hypothalamus and general hierarchical control of endocrine function
W Nov 5
Renal, Respiratory, and GI Physiology
F Nov 7
Control of Growth and Metabolism. Growth Hormone &Thyroid
B: 1023-1034, 1035-1048
M Nov 10
Adrenal (both cortex and medulla)
W Nov 12
F Nov 14
Parathyroid (Calcium Metabolism, & Bone)
M Nov 17
B: Portions of Chap. 53, 54, 55
W Nov 19
Organization Of Central Nervous System
B: 257-264 & 273-279
F Nov 21
Nov 24, 26, 28
M Dec 1
Sensory Coding & Somatosensory System
B: 352-358, 370-374
W Dec 3
B: 331-343, 368-370
F Dec 5
Hearing and Balance
B: 343-352, 374-376