C&MP 550a: Physiological Systems

Course Listings

  • Cellular and Molecular Physiology: C&MP 550a
  • Biomedical Engineering: BENG 350a
  • Engineering and Applied Science: ENAS 550a
  • Molecular and Cellular Developmental Biology: MCDB 310a/550a

Course Information

Web site for course information: https://classesv2.yale.edu/portal/ 
Weekly quiz websitehttp://courseinfo.med.yale.edu

Classes:   MWF 9:25-10:15 am
Location:  211 Mason Laboratory
Format:  36 Lectures, weekly quizzes, two midterm examinations, final examination.
Discussion Sections:  Students will be assigned to one discussion section M 7-8pm; M 8-9pm; T 7-8pm; or T 8-9pm.

Additional weekly meeting for graduate students:

Wednesdays with Instructor in SHM B-145 at 5 to 6pm.

Instructors 

Lead Instructor: Mark Saltzman, Ph.D.

Graduate Student Conference Leader:  Emile Boulpaep, M.D.

InstructorsOfficeEmail
Peter S. Aronson, M.D.TAC S-255peter.aronson@yale.edu
Emile Boulpaep, M.D.SHM B-142emile.boulpaep@yale.edu
Michael Caplan, M.D., Ph.D.SHM B116michael.caplan@yale.edu
Elizabeth Holt, M.D., Ph.D.LLCI 101elizabeth.holt@yale.edu
Michael Nitabach, Ph.D., J.D.SHM BE 29michael.nitabach@yale.edu

Mark Saltzman, Ph.D

BCT 227

mark.saltzman@yale.edu

Teaching Fellows & Discussion Section Leaders:
TBA

Course Description

The course develops a foundation in human physiology by examining the homeostasis of vital parameters within the body, and the biophysical properties of cells, tissues, and organs. Basic concepts in cell and membrane physiology are synthesized through exploring the function of skeletal, smooth, and cardiac muscle. The physical basis of blood flow, mechanisms of vascular exchange cardiac performance and regulation of overall circulatory function are discussed. Respiratory physiology explores the mechanics of ventilation, gas diffusion, and acid-base balance. Renal physiology examines the formation and composition of urine and the regulation of electrolyte, fluid, and acid-base balance. Organs of the digestive system are discussed from the perspective of substrate metabolism and energy balance. Hormonal regulation is applied to metabolic control and to calcium, water, and electrolyte balance. The biology of nerve cells is addressed with emphasis on synaptic transmission and simple neuronal circuits within the central nervous system. The special senses are considered in the framework of sensory transduction. Weekly discussion sections provide a forum for in-depth exploration of topics. Graduate students evaluate research findings through literature review and weekly meetings with the instructor.

Nature and amount of work required

Text (BENG 350a, MCDB 310a): Berne and Levy "Physiology", Koeppen and Stanton , 2008 6th edition

Text (ENAS 550a, MCDB 550a, CMP 550a):Textbook of Medical Physiology (2002) by Walter Boron and Emile Boulpaep, W.B. Saunders Company

Number of pages of reading per week: ~ 50 to 70; indicated for each lecture.
Quizzes and Discussion Sections: (20% of grade)
Midterm: Two midterms (each 20% of grade).
End of term: Final examination (40% of grade).
Examination format: multiple choice, true-false, & short answer.
Graduate students: weekly meeting and report (20% of grade).

Fall 2008 Schedule

Date

Instructor

Topic   

Reading Pages

W Sep 3

Saltzman

Homeostasis: levels of organization, body systems, feedback.

B: 3-6; 9-49

F Sep 5

Saltzman

Plasma Membrane: Organization & Signalling.

B: 9-49 & 50-54; & 87-113

M Sep 8

Saltzman

Membrane Transport: Potentials, Fluxes, and Active Transport

B: 54-72

W Sep 10

Saltzman

Electrophysiology of Cell Membranes

B: 145 - 154

F Sep 12

Saltzman

Neuronal Physiology & Nerve Conduction

B: 172-203

M Sep 15

Saltzman

Synaptic Transmission Neuromuscular Junction

B: 204-229

W Sep 17

Saltzman

Skeletal Muscle: organization, excitation & contraction, mechanics.

Muscle Properties: fiber types, feedback, smooth & cardiac.

B: 230-254

F Sep 19

Boulpaep

Organization of the Cardiovascular System

Hemodynamics

B: 423-446

M Sep 22

Boulpaep

Arteries, Veins, Microcirculation and Lymphatics.

B: 447-482

W Sep 24

Boulpaep

Cardiac electrophysiology

B: 483-507

F Sep 26

Boulpaep

The Heart as a Pump

B: 508-533

M Sep 29

Boulpaep

Control of Blood Pressure, Cardiac Output and Venous Return.

B: 534-557

W Oct 1

Saltzman

Overview and Mechanics of Respiration

B: 593-632

F Oct 3

MIDTERM #1

Membrane Function, Excitability, and Cardiovascular Physiology

M Oct 6

Saltzman

Acid-Base Relationships

B: 633-653

W Oct 8

Saltzman

Carriage and diffusion of oxygen and carbon dioxide

B: 654-685

F Oct 10

Boulpaep

Ventilation-Perfusion and Acid-Base Balance

B: 686-711

M Oct 13

Boulpaep

Control of Respiration

B: 712-734

W Oct 15

Aronson

Organization of the Urinary System.

Renal clearance; Reabsorption and Secretion

B: 737-755

F Oct 17

Aronson

Glomerular Filtration and Renal Blood Flow

B: 757-773

M Oct 20

Aronson

Renal Handling of Na and Cl

B: 774-789

W Oct 22

Aronson

Urine Concentration and Dilution

Water Balance

B: 828-844

F Oct 24

Aronson

Renal Mechanisms of Acid-Base Balance

B: 845-860

M Oct 27

Aronson

Integrative Renal Function

W Oct 29

Caplan

Digestion: Pancreas, Liver, Intestines

B: 947-967, Portions of Ch.42, 45

F Oct 31

Caplan

Digestive Tract and Regulation

B: 879-907

M Nov 3

Holt

Pituitary/hypothalamus and general hierarchical control of endocrine function

B: 1005-1021

W Nov 5

MIDTERM #2

Renal, Respiratory, and GI Physiology

F Nov 7

Holt

Control of Growth and Metabolism. Growth Hormone &Thyroid

B: 1023-1034, 1035-1048

M Nov 10

Holt

Adrenal (both cortex and medulla)

B: 1049-1065

W Nov 12

Holt

Endocrine Pancreas

B: 1066-1085

F Nov 14

Holt

Parathyroid (Calcium Metabolism, & Bone)

B: 1086-1102

M Nov 17

Saltzman

Reproductive Physiology

B: Portions of Chap. 53, 54, 55

W Nov 19

Nitabach

Organization Of Central Nervous System

B: 257-264 & 273-279

F Nov 21

Nitabach

Chemical Senses

B:326-332

Nov 24, 26, 28

FALL RECESS

M Dec 1

Nitabach

Sensory Coding & Somatosensory System

B: 352-358, 370-374

W Dec 3

Nitabach

Vision

B: 331-343, 368-370

F Dec 5

Nitabach

Hearing and Balance

B: 343-352, 374-376