Neurobiology of Addiction
Addiction puts a great burden on affected individuals and their families, causing widespread morbidity and behavioral dysfunction. Crime associated with drug abuse and the control of addictive therapeutics pose great legal and societal challenges. Drugs of addiction induce fundamental changes in brain biochemistry, activating neuronal reward circuits and acting as neuronal and cardiovascular stimulants. Research in the Department of Pharmacology aims to understand how addictive agents such as nicotine, amphetamines or cocaine affect neurotransmitter receptors and transporters, and how they change neuronal signal transduction to initiate addiction. Other efforts focus on the discovery of novel analgesics that may replace addictive analgesics treatments in the future.
Addiction Image Gallery
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- Cytoplasmic surface view of an inward-facing model of LeuT, a bacterial homologue of neurotransmitter transporters. Leucine (yellow) and sodium (blue) in their binding sites are visible through an aqueous pathway lined by residues (red) corresponding to positions with cytoplasmic accessibility in the cocaine-sensitive serotonin transporter. From the Rudnick lab. Physiology 2009 Dec;24:377.
- The pathway through which substrate (yellow) and ions (blue) diffuse from their binding sites in serotonin transporter (a target for MDMA, ecstasy) to the cytoplasm is lined by parts of transmembrane helices 1 (red), 5 (lime), 6 (green) and 8 (cyan). From the Rudnick lab, PNAS 2008 105:10338