The structure, function, and pharmacologic inhibition of FGF23
Research Faculty & Summary
V.P. Eswarakumar, Co-investigator
FGFs mediate their responses by binding to and activating a family of four receptor tyrosine kinases (FGFRs 1 – 4). FGFRs 1 – 3 have two isoforms produced by alternate splicing which differ in their ligand-binding specificities and tissue expression patterns.