Terence Keith Trow MD

Associate Professor of Medicine (Pulmonary)

Research Interests

Pulmonary Arterial Hypertension; Combination Therapy in Pulmonary Arterial Hypertension; Biomarkers to follow treatment success in Pulmonary Arterial Hypertension


Research Summary

The Pulmonary Hypertension Center at Yale is involved in industry sponsored studies of combination therapy in pulmonary arterial hypertension treatment. This involved looking at established therapies usually used alone and seeing if further gains can be made by using them together.
The Center is participating in the RESPIRE registry, looking at factors that influence patient compliance with inhaled iloprost therapy.
We are also interested in pulmonary arterial blood and systemic serial blood sample testing for a variety of biomarkers that may prove to be useful in knowing if treatments are working or failing in this disease, and a biorepository and database currently being developed.


Selected Publications

  • Cho WK, Lee CM, Kang MJ, Huang Y, Giordano FJ, Lee PJ, Trow TK, Homer RJ, Sessa WC, Elias J A, Lee CG. Il-13 induces pulmonary vascular remodeling and hyemodynamic changes via an IL-13 receptor alpha-2-arginase-2-dependent pathway. American Journal of Physiology -Lung Cellular and Molecular Physiology 2013; 304:L112-L124.
  • Sauler M, Fares WH, Trow TK. Standard nonspecific therapies in the management of pulmonary arterial hypertension. Clin Chest Med 2013; 34:799-810.
  • Forfia P, Trow TK. Diagnosis of pulmonary arterial hypertension. Clin Chest Med 2013;34: 665-682.
  • Gutierrez A, Sauler M, Mitchell JM, Siegel MD, Trow, TK, Bachetta M, Fares WH. Unresolved pulmonary embolism leadintg to a diagnosis of pulmonary artery sarcoma. Heart and Lung 2014
  • Trow, TK. Recent findings on pulmonary hypertension. Clin Chest Med 2013;34:xii-xiv.
  • Taichman, D, Ornelas J, Chung L, Klinger J, Lewis S, Palevsky H, Rich S, Sood N, Trow, TK, Yung R, Elliott CG, Badesch D. Pharmacological Therapy for Pulmonary Arterial Hypertension in Adults: CHEST Guidelines. Chest 2014, 146
  • Fares WH, Trow TK. Targeted approaches to the treatment of pulmonary hypertension. Thera Adv Resp Dis, 2012; 0(0): 1-13. DOI:10.1177/1753465812441849.
  • Li W, Niu B, Henderson K, Northrup V, Pollock JS, Trow TK, Fahey J, White RI. Reproducibility of oxygen saturation monitoring during six-minute walk test and exercise stress test in patients with pulmonary arteriovenous malformations associated with hereditary hemorrhagic telangiectasia. Pediatr Cardiol (published on line 19 February, 2011).
  • Lane CR, Trow TK. Pulmonary hypertension and pregnancy. Clin Chest Med 2011; 32: 165-174.
  • Trow TK, Argento AC, Rubinowitz AN, Decker R. A 71-year-old with myelofibrosis, hypoxemia, and pulmonary hypertension. Chest 2010;138:1506-1510.

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