Shilpa Hattangadi MD
Assistant Professor of Pediatrics (Hematology / Oncology) and of Pathology; Assistant Professor, Pathology
Terminal erythroid development, hematopoiesis; Bone marrow failure; Red cell aplasia; Chromatin condensation; Nuclear protein export; Proteomics; Genomics; transcriptional regulation; Histone modification; Post-transcriptional modification of hematopoietic regulators
We have focused on understanding the very late stages of normal murine red blood cell development, from committed progenitors to circulating red blood cells (RBCs). This is important (1) to learn why certain RBC disorders develop in the first place, but also (2) to help overcome one of the challenges in the latest advancement of red blood cells grown in culture for transfusion created from patients' own hematopoietic stem cells: poor enucleation. Our most recent focus on red blood cell development has been on how enucleation is dependent on nuclear protein export, how the nucleus condenses, and how histones are replaced in the condensing red cell nucleus before it is extruded. We are also interested in identifying new genetic causes and/or modifiers of bone marrow failure syndromes and are interested in creating new mouse models of cytopenias found in children using the humanized mouse system here at Yale.