Clifford W Bogue MD

Professor of Pediatrics (Critical Care); Vice Chair, Pediatrics; Chief, Critical Care Medicine; Director, Program in Vertebrate Development; Interim Chief, Gastroenterology and Hepatology

Research Interests

Role of homeobox transcription factors in early liver and cardiovascular development; Stem cells in organ repair and regeneration

Current Projects

  • Hhex – a homeobox gene essential for liver development. In this project, we are using mice with a liver-specific deletion of Hhex, derived in my lab, to gain insight into liver cell differentiation and bile duct morphogenesis.
  • Mechanism of polycystic liver disease in Hhex mutant mice. In this project, we are studying the role that Hhex deletion in the embryonic liver leads to polycystic liver disease.
  • Hhex and cardiovascular development. Hhex is critically important for normal heart and blood vessel development. This project focuses on the molecular mechanisms by which embryonic cardiovascular development is dependent on normal Hhex levels.


Research Summary

The major focus of my research is to understand the molecular control of organ formation and cell-type specification. In particular, we are focusing on the role that homeobox genes play in early organogenesis, specifically the Hhex gene. Based on a null mutation of Hhex generated in my laboratory, we have determined that Hhex is crucial for early liver budding and morphogenesis, cardiovascular development, and lymphopoiesis. We plan to determine the precise role of Hhex in these critical developmental processes and the factors with which it interacts using mouse molecular genetics, conditional gene knockouts, and transgenic overexpression in specific cells and tissues. The two major areas of focus in the lab are the roles that Hhex plays in liver and cardiovascular development. By studying the specific role of Hhex during development, we will gain important insight into the basic developmental mechanisms involved in early organogenesis of a number of different organs. Ultimately, we plan to use the knowledge obtained by our study of the basic mechanisms of organ development to repair and regenerate organs and tissues in humans.

Extensive Research Description

The major focus of my research is to understand the molecular control of organ formation and cell-type specification. In particular, we are focusing on the role that homeobox genes play in early organogenesis, specifically the Hhex gene. Based on a null mutation of Hhex generated in my laboratory, we have determined that Hhex is crucial for early liver budding and morphogenesis, cardiovascular development, and lymphopoiesis. We plan to determine the precise role of Hhex in these critical developmental processes and the factors with which it interacts using mouse molecular genetics, conditional gene knockouts, and transgenic overexpression in specific cells and tissues. The two major areas of focus in the lab are the roles that Hhex plays in liver and cardiovascular development. By studying the specific role of Hhex during development, we will gain important insight into the basic developmental mechanisms involved in early organogenesis of a number of different organs. Ultimately, we plan to use the knowledge obtained by our study of the basic mechanisms of organ development to repair and regenerate organs and tissues in humans.


Selected Publications

  • Faustino EVS, Hirshberg EL and Bogue, CW. (2012) Hypoglycemia in critically-ill children. J Diabetes Sci Technol, 6:48-57.
  • Faustino, EV and Bogue, CW. (2010) Relationship between hypoglycemia and mortality in critically ill children. Pediatr Crit Care Med, 11(6):690-8.
  • Paz H, Lynch MR, Bogue CW, and Gasson JC. (2010) The homeobox gene Hhex regulates the earliest stages of definitive erythropoiesis. Blood, 116(8):1254-62.
  • Weinzimmer S, Canarie, MF, Faustino, EVF, Tamborlane, WV, Bogue, CW (2008) , Disorders of Carbohydrate Metabolism, Rogers Textbook of Pediatric Intensive Care, , Philadelphia, Lippincott Williams and Wilkins, 1599-1614, Published
  • Canarie MF, Bogue CW, Banasiak KJ, Weinzimer SA, Tamborlane WV (Oct 2007) Decompensated hyperglycemic hyperosmolarity without significant ketoacidosis in the adolescent and young adult population., Journal of pediatric endocrinology & metabolism : JPEM, 20(10)1115-24
  • Hunter MP, Wilson CM, Jiang X, Cong R, Vasavada H, Kaestner KH, Bogue CW (2007) The homeobox gene Hhex is essential for proper hepatoblast differentiation and bile duct morphogenesis., Dev Biol, 308(2)355-67
  • Bogue, CW (2007) , Infectious Disease-Associated Syndromes, Pediatric Critical Care Medicine: Basic Science and Clinical Evidence, London, Springer-Verlag, 1511-1522, PublishedISBN=978-1-84628-4

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