Shilpa Hattangadi, MD

Assistant Professor of Pediatrics (Hematology / Oncology) and of Pathology; Assistant Professor, Pathology

Physician Biography

If you are concerned that your child has developed bone marrow failure or has low blood counts of some type, we have a comprehensive Bone Marrow Failure and Cytopenias Center here as one of our programs at the Smilow Pediatric Hematology-Oncology Clinic. Families like yours come to the Bone Marrow Failure and Cytopenias Center to obtain a diagnosis, get a second opinion, or establish and start a comprehensive treatment plan.

Bone marrow failure syndromes are diagnostically and therapeutically challenging. The clinical expertise here at Yale can be helpful in making an individualized plan of care for your child.

We offer complete diagnostic, therapeutic and support services for children with acquired and inherited bone marrow disorders and cytopenias. Our medical and transfusion therapies have achieved results that are among the best nationally.

Clinical Interests

  • Anemia, Aplastic
  • Anemia, Macrocytic
  • Anemia, Neonatal
  • Anemia, Refractory
  • Anemia, Sideroblastic
  • Bone Marrow Diseases
  • Hematology
  • Pancytopenia
  • Red-Cell Aplasia, Pure

Patient Care

Accepts new patients? Yes
Patient Type: Adolescent; Child
Referrals: From patients or physicians

Patient Care Organizations

Pediatrics: Hematology & Oncology


Cancer Center: Pediatric Hematology & Oncology Program

Yale Medical Group

Office of Cooperative Research

Board Certifications

  • Pediatric Hematology-Oncology AB of Pediatrics (2006)

Clinical Trials

Conditions Study Title
Myeloid and Monocytic Leukemia, Pediatrics
Brain and Nervous System, Pediatrics
Bones and Joints, Pediatrics
Leukemia, other
Bones and Joints, Pediatrics
Other Skin, Other Urinary, Ovary, Small Intestine, Soft Tissue, Pediatrics, Bones and Joints, Brain and Nervous System, Eye and Orbit, Hodgkin's Lymphoma, Kidney, Leukemia, other, Liver, Lymphoid Leukemia, Myeloid and Monocytic Leukemia, Non-Hodgkin's Lymphoma, Other Digestive Organ, Other Endocrine System, Other Female Genital, Other Male Genital, Other Respiratory and Intrathoracic Organs
Leukemia, not otherwise specified, Pediatrics
Brain and Nervous System, Phase I, Pediatrics
Non-Hodgkin's Lymphoma, Pediatrics
Hodgkin's Lymphoma, Pediatrics
Soft Tissue, Pediatrics
Brain and Nervous System, Pediatrics
Bones and Joints, Pediatrics
Lymphoid Leukemia, Pediatrics
Eye and Orbit, Pediatrics
Other Respiratory and Intrathoracic Organs, Pediatrics
Myeloid and Monocytic Leukemia, Pediatrics
Lymphoid Leukemia, Pediatrics
Brain and Nervous System, Pediatrics
Soft Tissue, Pediatrics

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Contact Info

Shilpa Hattangadi, MD
Patient Care Location
Pediatric Hematology & OncologySmilow Cancer Hospital at Yale - New Haven
35 Park Street, Ste 7th floor

New Haven, CT 06511
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Mailing Address
Pediatric Hematology-Oncology
333 Cedar Street

New Haven, CT 06520
Erythroid Terminal Differentiation

A set number of characteristic cell divisions (3 in mouse, 4 in humans) from the progenitor to the final erythroblast result in decreased cell size. A distinct expression program results in hemoglobin production, making the cytoplasm more eosinophilic. Nuclear condensation ensues and culminates in enucleation only in mammals. We study this last step of terminal erythropoiesis.