Gastroenterology; Hepatitis; Immune Tolerance; Liver Diseases; Pediatrics; Liver Transplantation
Dr Ekong is interested in developing ways to predict children who can discontinue their anti-rejection medications (immunosuppression) following liver transplantation and prior to joining the faculty at Yale, she was the center Principal Investigator on a clinical study on Immunosuppression Withdrawal in Pediatric Liver Transplant Recipients, conducted by the Immune Tolerance Network (ITN) and sponsored by the National Institute of Allergy and Infectious Diseases (NIAID).
Specialized Terms: Immune tolerance following pediatric liver transplantation; Immune dysregulation in autoimmune hepatitis; Immune mediated liver disease.
Extensive Research Description
Dr Ekong's research interest includes immune tolerance following liver transplantation and prior to joining the faculty at Yale, was the center Principal Investigator on a clinical study on Immunosuppression Withdrawal in Pediatric Liver Transplant Recipients, conducted by the Immune Tolerance Network (ITN) and sponsored by the National Institute of Allergy and Infectious Diseases (NIAID). She is also interested in the role regulatory T cell dysfunction plays in the immune pathogenesis of de novo autoimmune hepatitis and autoimmune hepatitis.
- The role of sodium chloride and the Treg/Th17 axis in Autoimmune Hepatitis
This project is investigating if a salt restriction protocol will improve immune parameters in patients with autoimmune hepatitis in vivo?
- De NovoAutoimmune Hepatitis in Pediatric Liver Transplantation
This project is investigating if the factors that contribute to regulatory T cells becoming ineffective in children who develop de novo autoimmune hepatitis.
- Studies of Pediatric Liver Transplantation (SPLIT)
The mission of the Studies of Pediatric Liver Transplantation is to improve the outcome, and provide educational and advocacy resources for children who require, or have received, liver transplantation in the United States and Canada.
- Ekong UD, et al. Successful Resolution of Inflammation and Increased Regulatory T cells in Sirolimus Treated Post Transplant Allograft Hepatitis. Pediatr Transplant 2012 Mar; 16(2):165-175.
- Feng S, Ekong UD, Lobritto S, et al. Complete Immunosuppression Withdrawal and Subsequent Allograft Function Among Pediatric Recipients of Parental Living Donor Liver Transplants. JAMA 2012; 307(03):283-293.PMID: 22253395.
- Ekong UD, et al., Lymphocyte activation markers may predict the presence of donor specific alloreactivity in pediatric living related liver transplant recipients. Hum Immunol 2011 May; 72(5):392-7. PMID: 21315129.
- Ekong UD, Alonso EM et al. Once Daily Calcineurin Inhibitor Monotherapy in Pediatric Liver Transplantation. AJT 2010. 10; 883-888. PMID: 20420643
- Ekong UD, Miller SD, O’Gorman MRG. In- vitro assays of allosensitization. Pediatr Transplant 2009 Feb; 13(1):25-34. PMID 19017286.
- Ekong UD, Hector Melin-Aldana, Roopa Sheshadri, Joan Lokar, Dave Harris, Peter F. Whitington, Estella M Alonso. (2008)Graft histology characteristics in long-term survivors of pediatric liver transplantation.
- Guideline for the Evaluation of Cholestatic Jaundice in Infants: Joint Recommendations of the North American Society for Pediatric Gastroenterology, Hepatology, and Nutrition (NASPGHAN) and the European Society for Pediatric Gastroenterology, Hepatology, and Nutrition (ESPGHAN).
- Five-year histological and serological follow-up of operationally tolerant pediatric liver transplant recipients enrolled in WISP-R.
- Production of Proinflammatory Cytokines by Monocytes in Liver-Transplanted Recipients with De Novo Autoimmune Hepatitis Is Enhanced and Induces TH1-like Regulatory T Cells.
- Autoimmune Liver Disease Post-Liver Transplantation: A Summary and Proposed Areas for Future Research.
- Extended follow-up of pediatric liver transplantation patients receiving once daily calcineurin inhibitor.
- Posttransplant metabolic syndrome in the withdrawal of immunosuppression in Pediatric Liver Transplant Recipients (WISP-R) pilot trial.
- Evaluation of the pediatric patient for liver transplantation: 2014 practice guideline by the American Association for the Study of Liver Diseases,
- Paediatric hepatocellular carcinoma due to somatic CTNNB1 and NFE2L2 mutations in the setting of inherited bi-allelic ABCB11 mutations.
- Evaluation of the pediatric patient for liver transplantation: 2014 practice guideline by the American Association for the Study of Liver Diseases, American Society of Transplantation and the North American Society for Pediatric Gastroenterology, Hepatology and Nutrition.
- Successful treatment with rituximab of an Epstein-Barr virus-associated leiomyosarcoma occurring after liver transplantation.
- Rituximab as therapy for the recurrence of bile salt export pump deficiency after liver transplantation.
- The SPLIT research agenda 2013.
- Sirolimus as rescue therapy in pediatric autoimmune hepatitis.
- Liver transplantation followed by allogeneic hematopoietic stem cell transplantation for atypical mevalonic aciduria.
- The long-term liver graft and protocol biopsy: do we want to look? What will we find?