Research Experience

Yale University is well known for its cutting edge research activities. Fellows spend a minimum of two years in research activities, with many fellows extending the period of research training to three years. Extending the period of research experience provides fellows with additional time for course work and, more importantly, allows them to become involved in more challenging and technically demanding research projects. It is our belief that the acquisition of high quality research skills is fundamental to a viable long-term career in academic medicine. We have assembled a group of preceptors for research training which is broad based and represents some of the most outstanding investigators with expertise in a broad range of biomedical disciplines relevant to pediatric GI/ hepatology research. 

The choice of a particular preceptor and project is the most important decision facing each fellow. Because it is the philosophy of the program that preceptors should be chosen by trainees rather than assigned, each fellow is provided with extensive help in the form of information, advice and time to make a careful and deliberate selection of preceptor and project. In January, the first year fellow has limited clinical responsibilities and has more time and opportunities to meet with the faculty whose research programs are of possible interest to them.

Scholarship Oversight Committee

A formal Scholarship Oversight Committee (SOC) is established to mentor and guide each fellow in the first year. SOC is composed of at least 3 individuals i.e., the primary mentor supervising the fellow’s scholarly activity, a mentor for the fellow’s clinical and general career development, and a mentor with expertise in the particular area of scholarship that is being pursued by the fellow. Often there are additional mentors who are also members of SOC. The specific goals of SOC are:

  • To meet with the fellow at least 2 times a year. If there are concerns with the fellow's progress, meetings are expected to occur more frequently.
  • Complete evaluation/progress reports after each meeting to assess progress and detail accomplishments.
  • Review and approve the proposed research plan for first year fellows.
  • Attend the Thursday morning conferences to hear their fellow's presentations.
  • Evaluate the fellow's written product of scholarly activity.

Fellow Publications

Our previous fellows have been very productive in research and have a high likelihood of progressing to academic careers as exemplified by these selected publications (the name of training fellow is in bold): 

  1. Del Valle, A, Jones BF, Harrison LM, Chadderdon RC, Cappello M. Isolation and molecular cloning of a secreted hookworm platelet inhibitor from adult Ancylostoma caninum. Mol Biochem Parasitol, 2003. 129(2): p. 167-77. 
  2. Denson, LA, Sturm E, Echevarria W, Zimmerman TL, Makishima M, Mangelsdorf DJ, Karpen SJ. The orphan nuclear receptor, shp, mediates bile acid-induced inhibition of the rat bile acid transporter, ntcp. Gastroenterology, 2001. 121(1): p. 140-7. 
  3. Echevarria, W, Leite MF, Guerra MT, Zipfel WR, Nathanson MH. Regulation of calcium signals in the nucleus by a nucleoplasmic reticulum. Nat Cell Biol, 2003. 5(5): p. 440-6 
  4. Leite, MF, Thrower EC, Echevarria, W, Koulen P, Hirata K, Bennett AM, Ehrlich BE., Nuclear and cytosolic calcium are regulated independently. Proc Natl Acad Sci USA, 2003. 100(5): p. 2975-80. 
  5. Husain, SZ, Prasad P, Grant WM, Kolodecik TR, Nathanson MH, Gorelick FS. The ryanodine receptor mediates early zymogen activation in pancreatitis. Proc Natl Acad Sci USA, 2005. 102(40): p. 14386-91. 
  6. Sehgal, S, Guerra MT, Kruglov EA, Wang J, Nathanson MH. Protein 4.1N does not interact with the inositol 1,4,5-trisphosphate receptor in an epithelial cell line. Cell Calcium, 2005. 38(5): p. 469-80. 
  7. Gathungu GN, Pashankar DS, Sarita-Reyes CD, Zambrano E, Reyes-Mugica M, Brueckner M, Mistry PK, Husain SZ. Microvillus inclusion disease associated with the coarctation of the aorta bicuspid aortic valve. J Clin Gastroenterol. 2008 Apr;42(4):400-3. 
  8. Gathungu G, Zhang CK, Zhang W, Cho JH. A two-marker haplotype in the IRF-5 gene is assoaited with inflammatory bowel disease in a North American Cohort. Genes Immun 2012 
  9. Bultron G, Latif U, Park A, Phatak U, Pashankar D, Husain SZ. Acute pancreatitis in a child with celiac disease. J Pediatr Gastroenterol Nutr. 2009 Jul;49(1):137-8. 
  10. Park AJ, Latif SU, Ahmad MU, Bultron G, Orabi AI, Bhandari V, Husain SZ. A comparison of presentation and management trends in acute pancreatitis between infants/toddlers and older children. J Pediatr Gastroenterol Nutr. 2010 Aug;51(2):167-70. 
  11. Bultron G, Kacena K, Pearson D, Boxer M, Yang R, Sathe S, Pastores G, Mistry PK. The risk of Parkinson’s disease in type 1 Gaucher’s disease. J Inherit Metab Dis 2010;33:167-73. 
  12. Phatak UP, Park AJ, Latif SU, Bultron G, Pashankar DS, Husain SZ. Recurrent acute pancreatitis in a child with primary hyperparathyroidism. J Pediatr Endocrinol Metab. 2008 Dec;21(12):1191-4. 
  13. Phatak UP, Seo-Mayer P, Jain D, Selbst M, Husain S, Pashankar DS. Mycophenolate mofetil-induced colitis in children. J Clin Gastroenterol. 2009 Nov-Dec;43(10):967-9. 
  14. Phatak UP, Pashankar DS. Obesity and gastrointestinal disorders. J Pediatr. 2009 Oct;155(4):599 Phatak UP , Pashankar DS. Constipation in Pediatric Practice : Gastroenterology, Hepatology, and Nutrition , Bishop WP, ed. McGraw-Hill Professional, New York, NY 2010.;55-63.. 
  15. Phatak UP, Johnson S, Husain SZ, Pashankar DS. Two-day bowel preparation with polyethylene glycol 3350 and bisacodyl : A new safe and effective regimen for colonoscopy in children. J Pediatr Gastroenterol Nutr 2011; 53:71-4. 
  16. Stein P, Yu H, Jain D, Mistry PK. Hyperferritinemia and iron overload in type 1 Gaucher’s disease. Am J Hematol 2010; 85:472-6. 
  17. Stein P, Zhang C, Pastores GM, Wang A, Liu J, Yang R, Cho J, Gregersen P, Zhao H, Mistry PK. Genome-wide Association Study of N370S Homozygous Gaucher Disease Reveals the Candidacy of CLN8 gene as a Genetic Modifier Contributing to Extreme Phenotypic Variation in Gaucher Disease . Amer J Hematol 2012;87:377-83. 
  18. Stein P, Yang R, Liu J, Pastores GM, Mistry PK. Evaluation of high density lipoprotein as a circulating biomarker of a Gaucher disease activity. J Inherit Metab Dis. 2011 Apr;34(2):429-37. 
  19. Stein P, Malhotra A, Haims A, Pastores GM, Mistry PK. Focal splenic lesions in type I Gaucher disease are associated with poor platelet and splenic response to macrophage-targeted enzyme replacement therapy. J Inherit Metab Dis. 2010 Dec;33(6):769-75. 
  20. Lo SM, Stein P, Mullaly S, Bar M, Jain D, Pastores GM, Mistry PK. Expanding spectrum of the association between Type I Gaucher disease and cancers: a series of patients with up to 3 sequential cancers of multiple types--correlation with genotype and phenotype. Am J Hematol. 2010 May;85(5):340-5. 
  21. Cheng SX, Gathungu G, Pashankar D, Jain D, Husain SZ. Jejunal adaptation in a prepubertal boy after total ileal resection and jejunostomy placement: afour-year follow-up. J Clin Gastroenterol. 2011 Nov-Dec;45(10):846-9. 
  22. Cheng SX. Calcium-sensing receptor inhibits secretagogue-induced electrolyte secretion by intestine via the enteric nervous system. Am J Physiol Gastrointest Liver Physiol. 2012 Apr 19. [Epub ahead of print]