Eda Cengiz, MD, MHS, FAAP

Assistant Professor of Pediatrics (Endocrinology)

Research Interests

Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 1; Diabetic Angiopathies; Diabetes Complications

Research Organizations

Pediatrics: Pediatric Endocrinology: Children's Diabetes Program

Research Summary

  • Pharmacokinetics & pharmacodynamics of insulin therapy;
  • Artificial Pancreas Project (APP);
  • Preservation of beta cells for children with new onset type 1 diabetes;
  • Pediatric Diabetes Consortium (PDC) project: building a database to monitor diabetes management and complications;
  • Integrating technology with diabetes care: use of new high-tech devices and methods to improve insulin delivery and function;
  • Detecting early cardiovascular disease markers for children and adolescents with type 1 diabetes.

Extensive Research Description

  • Closed loop insulin delivery system
  • Clamp studies to demonstrate pharmacokinetics and pharmacodynamics of insulin
  • Detecting early cardiovascular disease markers for children with type 1 diabetes including peripheral arterial tonometry
  • Pediatric Diabetes Consortium:utilizing a database registry to assess treatment approaches for children and youth with new-onset type 1 diabetes
  • Anti -CD3 treatment for preservation of beta cells in children with new onset type 1 diabetes
  • Artificial pancreas project
  • PKPD of insulin therapy
  • Pediatric Diabetes Consortium
  • Glucose sensor studies
  • Effect of the Human Recombinant Hyaluronidase (rHuPH20) on the Pharmacokinetic & Pharmacodynamic (PK/PD) Properties of Lispro and Aspart Insulin using the Euglycemic Clamp and on Meal-related Glucose Excursions during Open- and Closed-loop Insulin Delivery.

Selected Publications

  • Putting Brakes on Insulin Pump Infusion to Prevent Hypoglycemia. Eda Cengiz. Journal of Diabetes Science and Technology, Volume 5, Issue 5, September 2011.
  • Teplizumab for treatment of type 1 diabetes (Protégé study): 1-year results from a randomized, placebo-controlled trial. Protege Trial Collaborator- Eda Cengiz. Lancet. 2011 Aug 6;378(9790):487-97. Epub 2011 Jun 28.
  • The bridge to insulin pump therapy: a bid regimen with NPH and detemir insulin during initial treatment of youth with type 1 diabetes (T1D). Eda Cengiz, Jennifer L. Sherr, Ayca Erkin-Cakmak, Stuart A. Weinzimer, Erin N. Burke, Kristin A. Sikes , Andrea A
  • New generation diabetes management: glucose sensor augmented insulin pump therapy. Eda Cengiz, Jennifer L. Sherr, Stuart A. Weinzimer, William V. Tamborlane. Expert Review of Medical Devices, 2011 Jul;8(4):449-58.
  • Pediatric Diabetes Consortium Work Group, Eda Cengiz. The pediatric diabetes consortium: improving care of children with type 1 diabetes through collaborative research. Diabetes Technology and Therapeutics 2010 Sep;12(9):685-8.
  • Insulin & Diabetes Mellitus. Tania S. Burgert, Eda Cengiz, William V. Tamborlane.Neonatal & Pediatric Pharmacology 4th Edition, Lippincott Williams & Wilkins, 2010; Chapter 52, 773-778.
  • A Tale of Two Compartments: Interstitial vs. Blood Glucose Monitoring. Eda Cengiz, William V Tamborlane Diabetes Technology and Therapeutics Diabetes Technology and Therapeutics 2009 Jun;11 Suppl 1:S11-6..
  • Is an Automatic Pump Suspension Feature Safe for Children with Type 1 Diabetes?An Exploratory Analysis with a Closed-Loop System. Eda Cengiz, Karena L Swan, William V Tamborlane, Garry M Steil, Amy T Steffen, Stuart A Weinzimer Diabetes Technology and Th
  • From pumps to prevention: recent advances in the treatment of type 1 diabetes Jennifer Sherr, MD, Eda Cengiz, MD, and William V. Tamborlane, MD Drug Discov Today. 2009 Oct;14(19-20):973-81. Epub 2009 Jul 4. Review.
  • Recent advances in the treatment of type 1 diabetes in children. Karena L Swan, Eda Cengiz, William V Tamborlane Annals of Pediatrics 68:1-4, 2008
  • The early pharmacodynamic and pharmacokinetic effects of mixing lispro with glargine insulin: results of glucose clamp studies in youth with type 1 diabetes. Cengiz E, Tamborlane WV, Martin-Fredericksen M, Dziura J, Weinzimer SA. Diabetes Care. 2010 Feb

Edit this profile

Contact Info

Eda Cengiz, MD, MHS, FAAP
Patient Care Location
Yale Pediatric Endocrinology1 Long Wharf Drive, Ste 2nd Floor
New Haven, CT 06511
Mailing Address
PO Box 208064
New Haven, CT 06520-8064

Curriculum Vitae