Ania Magdalena Jastreboff MD, PhD

Assistant Professor of Medicine (Endocrinology) and of Pediatrics (Endocrinology); Assistant Professor of Pediatrics (Pediatric Endocrinology)

Research Interests

Obesity; Insulin resistance; Type 2 diabetes; Neural control of eating behaviors; Weight-loss maintenance; Dietary glycemic index, Diabetes technology tools, Transitions of care from pediatric to adult care

Research Summary

Dr. Jastreboff’s research seeks to elucidate neural mechanisms involved in obesity including neural control of eating behaviors. During her doctoral thesis work, Dr. Jastreboff became interested in understanding how metabolic perturbations, such as insulin resistance, hyperinsulinemia, leptin resistance, etc, affect neural mechanisms, which subsequently impact eating behavior and weight gain. To this end, she utilizes functional MRI to examine neural responses in obese adults and adolescents (insulin resistant and insulin sensitive) to various food cues (viewing images of high-calorie and low-calorie foods, ingestion of glucose or fructose drinks, etc). Dr. Jastreboff’s overarching goal is to conduct research that is clinically applicable for the treatment of obesity and has a clear public health impact to mitigate the obesity pandemic.

Selected Publications

  • Jastreboff AM, Lacadie C, Seo D, Kubat J, Van Name MA2, Giannini C, Savoye M, Constable RT, Sherwin RS, Caprio S, Sinha R. A role for leptin in exaggerated brain reward and emotion responses to food images in adolescent obesity. Diabetes Care. 2014 Aug 19. [Epub ahead of print]
  • Jastreboff AM, Sinha R, Lacadie C, Small D, Sherwin RS, Potenza MN. Neural correlates of stress- and food-cue–induced food craving in obesity: association with insulin levels. Diabetes Care. 2013 Feb; 36(2):394-402. PMCID: PMC3554293
  • Jastreboff AM. Paying our sleep debt in extra pounds. Science Translational Medicine.5:178. March 2013. DOI: 10.1126/scitranslmed.3006149
  • Jastreboff AM. Demystifying the “magical cure” for diabetes. Science Translational Medicine. Vol. 5, Issue 184, p. 184ec76. May 2013. DOI: 10.1126/scitranslmed.3006449
  • BAT Burns Fat? Cool. Science Translational Medicine. Vol. 5, Issue 202, p. 202ec148. September 2013. DOI: 10.1126/scitranslmed.3007485
  • Oxytocin Curbs Cookie Consumption. Science Translational Medicine. Vol. 5, Issue 208, p. 208ec173. October 2013. DOI: 10.1126/scitranslamed.3007768
  • Jastreboff AM, Gaiser EC, Gu P, Sinha R. Sex differences in the association between dietary restraint, insulin resistance, and obesity. Eating Behaviors. 2014 Apr; 15(2):286-90. PMCID: PMC4032476
  • Hairston KG, Ducharme JL, Treuth MS, Hsueh WC, Jastreboff AM, Ryan KA, Shi X, Mitchell BD, Shuldiner AR, Snitker S. Comparison of BMI and physical activity between Old Order Amish children and non-Amish children. Diabetes Care. 2013 Apr; 36(4):873-8. PMCID: PMC3609522
  • Sherwin R, Jastreboff AM. Year in Diabetes 2012: The Diabetes Tsunami. J Clin Endocrinol Metab. 2012 Nov 26. [Epub ahead of print] (PMID: 23185035)
  • Jastreboff AM, Sinha R, Lacadie C, Small D, Sherwin RS, Potenza MN. Neural Correlates of Stress- and Food- Cue–Induced Food Craving In Obesity: Association with insulin levels. Diabetes Care 2012 October 15 [Epub ahead of print] (PMID: 23069840)


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