Our research effort includes clinical and basic laboratory research. Clinical research projects are served by the Yale Center for Clinical Investigation, an NIH supported unit of which Dr. Tamborlane is Deputy Program Director and in which a large number of research protocols in all areas of endocrinology and metabolism are ongoing. There are both inpatient (HRU or Hospital Research Unit) and out-patient venues where clinical research projects are concentrated. At present, Dr. Caprio is using "state-of-the-art" techniques (insulin clamp, stable isotope turnover, and indirect calorimetry) to examine the metabolic and clinical complications of childhood obesity. Dr. Carpenter's primary interest is in calcium and mineral metabolism. Specific laboratory projects are focused on models of hypophosphatemic rickets syndromes. Both clinical and basic studies of bone and mineral metabolism are ongoing including the investigation of new therapies for hypophosphatemic rickets. Dr. Scott Rivkees is actively investigating the development of biology of the adenosine receptor in the CNS, and control of circadian rhythm. Finally, Dr. Stuart Weinzimer is performing studies related to automated insulin delivery and real-time glucose sensing as aids in the therapy of Type 1 Diabetes, and Dr. Tania Burgert, is performing studies related to the metabolic consequences of obesity in children.
Finally, Dr. Eda Cengiz, the newest addition to our faculty, is investigating pharmacokinetics and pharmacodynamics of insulin, early cardiovascular disease markers in Type 1 Diabetes and anti CD3 treatment for the preservation of beta cells. She is also a member of the artificial pancreas project research team.
Active liaison with the Endocrinology sections in the Departments of Internal Medicine, Obstetrics and Gynecology, Genetics, and Orthopaedics provide additional opportunities for clinical and laboratory research.
We currently use U.S. government funds to support post-doctoral trainees, which limits the availability of the fellowships to U.S. citizens. However, we have been able to support post-doctoral fellows from Britain, Europe, Asia and Israel who have been able to obtain home sources of funding (both governmental and private) for their training interests.