Edward Vincent Faustino MD

Assistant Professor of Pediatrics (Critical Care)

Research Interests

Glucose control in critically ill children; Prevention of deep venous thrombosis; Sedation in children with respiratory failure; Improving quality of care and safety in the PICU

Current Projects

1. Epidemiology of Central Venous Line-Related Deep Venous Thrombosis in Critically Ill Children. The goal of this study is to determine the incidence and outcomes of central venous line-related deep venous thrombosis in critically ill children.
2. Sedation Management in Pediatric Patients with Acute Respiratory Failure. The goal of this study is to test an innovative approach to sedation management of children with acute respiratory failure.
3. Genetic Variations and Biomarkers in Children with Acute Lung Injury. The goal of this study is to test the prediction that genetic variations in selected candidate genes and selected plasma biomarkers related to inflammation, coagulation, and/or surfactant are associated with the development of acute lung injury in children with parenchymal lung disease.
4. Prevention of Ventilator-Associated Pneumonia in Critically Ill Children. The goal of this project is to determine the incidence of ventilator-associated pneumonia in critically ill children and to develop a bundle to minimize its occurrence.
5. A Pilot Randomized Controlled Trial of Strict Blood Glucose Control utilizing eProtocol-Insulin in Pediatric ICUs. The objective of this study is to determine the feasibility of randomizing hyperglycemic critically ill children to either strict or liberal blood glucose control.

Research Summary

Dr. Faustino is involved in improving the outcomes and care of critically ill children. He is working on the prevention of the development of blood clots in this patient population. He is also involved in studies to improve the sedation of patients requiring mechanical assistance to breathe, to prevent the occurrence of lung infections in these patients and to improve survival by controlling blood sugar.

Extensive Research Description

Dr. Faustino is involved in patient-oriented clinical research and performance improvement. His primary research interest is the prevention of deep vein thrombosis in critically ill children. He has ongoing projects (1) to determine the population of critically ill children that will benefit the most from pharmacologic prophylaxis against deep vein thromobosis, and (2) to identify the optimal outcome measure for trials on prevention of deep vein thrombosis. He is also investigating glucose control in critically ill children, sedation in mechanically ventilated patients and ventilator-associated pneumonia.

Selected Publications

  • Faustino EVS, Spinella PC, Li S, Pinto MG, Stoltz P, Tala J, Card ME, Northrup V, Baker KE, Goodman TR, Chen L and Silva CT. Incidence and acute complications of asymptomatic central venous catheter-related deep venous thrombosis in critically ill children. J Pediatr in press.
  • Thompson CD, Vital-Carona J and Faustino EVS. The effect of tubing dwell time on insulin adsorption during intravenous insulin infusions. Diabetes Technol Ther in press.
  • Hirshberg EL, Sward K, Faustino EVS, Nadkarni V, Agus M, Morris AH and Lacroix J for the PALISI Network Investigators. Clinical equipoise regarding glycemic control: A survey of pediatric intensivist perceptions. Pediatr Crit Care Med in press.
  • Faustino EVS, Patel S, Thiagarajan RR, Cook, DJ, Northrup V and Randolph AG. Survey of pharmacologic thromboprophylaxis in critically ill children. Crit Care Med 39: 1773-78, 2011.
  • Faustino EVS, Lawson KA, Northrup V and Higgerson RA. Mortality-adjusted duration of mechanical ventilation in critically ill children with symptomatic central venous line-related deep venous thrombosis. Crit Care Med 39: 1151-56, 2011.
  • Faustino EV, Bogue CW. Relationship between hypoglycemia and mortality in critically ill children. Pediatr Crit Care Med. 2010 Jul 9; [Epub ahead of print]
  • Faraon-Pogaceanu C, Banasiak KJ, Hirshberg EL, Faustino EV. Comparison of the effectiveness and safety of two insulin infusion protocols in the management of hyperglycemia in critically ill children. Pediatr Crit Care Med. 2010 Jun 10; [Epub ahead of print]
  • Weinzimer SA, Canarie MF, Faustino EVS, Tamborlane WV and Bogue CW. Disorders of Glucose Metabolism. In: Rogers’ Textbook of Pediatric Intensive Care 4th ed edited by Nichols DG. Philadelphia, PA: Lippincott Williams & Wilkins, 2008, pp. 1599-1614.
  • Faustino EV and Apkon M. Persistent hyperglycemia in critically ill children. J Peds 146: 30-34, 2005.

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