John S Giuliano Jr, MD

Associate Professor of Pediatrics (Critical Care); Medical Director, Pediatric Transport Service; Associate Medical Director, Pediatric Extracorporeal Membrane Oxygenation (ECMO) Service; Associate Medical Director, Pediatric Intensive Care Unit

Research Interests

Research Organizations

Pediatrics: Pediatric Critical Care Medicine

Research Summary

John Giuliano, M.D, has focused his research interests around inflammation and the host’s response to sepsis/acute lung injury. To this end, he is involved in a translational research project looking at the role angiopoietins play in capillary leak from pediatric sepsis. Additionally, he is looking at the incidence of morbidity and mortality in pediatric patients admitted to the ICU with influenza. Finally, he is investigating the use of an antiseptic-impregnated central line dressing to see if it reduces catheter associated blood stream infections.

Extensive Research Description

John Giuliano, M.D, research interest has centered around our body’s inflammatory response to infection. His main interest lies in the release of vascular growth factors called angiopoietins. He has shown that ang-2 is significantly elevated when children with septic shock are admitted to the PICU and that these levels peak around day 2 of illness. This growth factor may play a role in the capillary leak phenomena seen in these patients. Along similar lines, he is studying plasma biomarkers released when children have severe influenza infections. He will also be conducting a RTC comparing CHG-impregnated dressings to the current clear dressings used to cover central lines in children. Reports on the biopatch, a CHG disk, have demonstrated significant skin irritation in this population without clear reductions in infection.

  • Describing the temporal kinetics of angiopoietin levels in children with varying degrees of sepsis.
  • Evaluating the biomarker profile of critically ill children with influenza infection
  • Understanding pediatric medication pharmacokinetics
  • Evaluating whether chlorhexidine-impregnated central line dressings in children reduce blood stream infections without causing skin breakdown

Selected Publications

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Contact Info

John S Giuliano Jr, MD
Patient Care Location
Yale Pediatric Critical Care MedicineYale-New Haven Children's Hospital
1 Park Street, Ste West Pavilion - 2nd Floor

New Haven, CT 06504
Mailing Address
Yale PediatricsPO Box 208064
New Haven, CT 06520-8064

Curriculum Vitae