John S Giuliano Jr, MD

Associate Professor of Pediatrics (Critical Care); Director, Pediatric Fellowship Program; Medical Director, Pediatric Transport Service; Associate Medical Director, Pediatric Extracorporeal Membrane Oxygenation (ECMO) Service

Research Interests

Critical Care; Inflammation; Pediatrics; Extracorporeal Membrane Oxygenation; Sepsis; Acute Lung Injury

Research Organizations

Pediatrics: Critical Care Medicine

Office of Cooperative Research

Research Summary

John Giuliano, M.D, has focused his research interests around inflammation and the host’s response to sepsis/acute lung injury. To this end, he is involved in a translational research project looking at the role angiopoietins play in capillary leak from pediatric sepsis. Additionally, he is looking at the incidence of morbidity and mortality in pediatric patients admitted to the ICU with influenza. He is investigating the use of an antiseptic-impregnated central line dressing to see if it reduces catheter associated blood stream infections. Finally, he is involved with improving the morbidity and mortality associated with pediatric endotracheal intubation.

Specialized Terms: Pediatric sepsis; Acute lung injury and the inflammatory response; Pediatric transport medicine; Pediatric endotracheal intubation

Extensive Research Description

John Giuliano, M.D, research interest has centered around our body’s inflammatory response to infection. His main interest lies in the release of vascular growth factors called angiopoietins. He has shown that ang-2 is significantly elevated when children with septic shock are admitted to the PICU and that these levels peak around day 2 of illness. This growth factor may play a role in the capillary leak phenomena seen in these patients. Along similar lines, he is studying plasma biomarkers released when children have severe influenza infections. He is also be conducting a RTC comparing CHG-impregnated dressings to the current clear dressings used to cover central lines in children. Reports on the biopatch, a CHG disk, have demonstrated significant skin irritation in this population without clear reductions in infection. Since many children with severe sepsis require an advanced airway, Dr. Giuliano is also investigating ways to improve the morbidity and mortality associated with this high risk procedure.

  • Describing the temporal kinetics of angiopoietin levels in children with varying degrees of sepsis.
  • Evaluating the biomarker profile of critically ill children with influenza infection
  • Understanding pediatric medication pharmacokinetics
  • Evaluating whether chlorhexidine-impregnated central line dressings in children reduce blood stream infections without causing skin breakdown
  • Reducing tracheal intubation associated events in children

Selected Publications

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Contact Info

John S Giuliano Jr, MD
Patient Care Location
Yale Pediatric Critical Care MedicineYale-New Haven Children's Hospital
1 Park Street, Ste West Pavilion - 2nd Floor

New Haven, CT 06504
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Mailing Address
Yale PediatricsPO Box 208064
New Haven, CT 06520-8064

Curriculum Vitae