Yale Pathology Tissue Services -YPTS

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  • YPTS  is a Pathology-based Central Tissue Resource Lab providing comprehensive tissue related services and material for investigators at Yale and beyond.
  • YPTS provides services as a shared resource of the Yale Cancer Center

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Mission

To provide the maximum amount and quality of human tissue for research at Yale University without impacting diagnostic quality, accuracy and safety in anatomic pathology.

Executive Summary

Human tissue, collected by physicians for diagnostic purposes, is an extremely valuable resource for translational research. However, this resource is limited in amount and constricted in scope of use by the fact that it initially belongs to the patient from whom it was taken, and once collected, is an asset of the institution. Its diagnostic usage supersedes all other uses. There are now a proposed set of policies and standard operating procedures that will provide for optimal management of pathology resources including fresh, frozen, and fixed tissue, included tissue from the Yale Pathology Departmental Archives. 

Leadership


Rimm, David L

Professor of Pathology and of Medicine (Medical Oncology); Director of Pathology Tissue Services; Director of Translational Pathology

Biography

Dr. David Rimm, is a Professor in the Department of Pathology at the Yale University School of Medicine. He completed an MD-PhD at Johns Hopkins University Medical School followed by a Pathology Residency at Yale and a Cytopathology Fellowship at the Medical College of Virginia. He is board certified in Anatomic Pathology and Cytopathology. At Yale since 1994, Dr. Rimm is the Director of Yale Pathology Tissue Services and the Yale Tissue Microarray Facility. He is a member of the Executive...

Dr. David Rimm, is a Professor in the Department of Pathology at the Yale University School of Medicine. He completed an MD-PhD at Johns Hopkins University Medical School followed by a Pathology Residency at Yale and a Cytopathology Fellowship at the Medical College of Virginia. He is board certified in Anatomic Pathology and Cytopathology. At Yale since 1994, Dr. Rimm is the Director of Yale Pathology Tissue Services and the Yale Tissue Microarray Facility. He is a member of the Executive Team in Pathology and serves as the Director of Translational Pathology. His lab group (15 researchers) focuses on quantitative pathology using the AQUA® technology invented in his lab with projects related to predicting response to therapy in breast cancer and predicting recurrence or metastasis in melanoma and lung cancer. He is currently supported by 9 grants from both public and private sources. He serves as a reviewer for the NIH and was a charter member of the Cancer Biomarkers Study Section. He is an editorial board member for 7 pathology journals and a member of the pathology committee for TransALLTO and TEACH (cooperative groups or therapeutic clinical trials). He is an author of over 275 peer-reviewed papers and 8 patents and was the scientific co-founder of HistoRx, a digital pathology company (sold to Genoptix in 2012) and Metamark Genetics, a prognostic determinant company.

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Vortmeyer, Alexander Oliver

Associate Professor of Pathology; Director, Neuropathology

Biography

Dr. Alexander Vortmeyer graduated from Hamburg University Medical School in 1987. From 1988 to 1994, he was trained in academic and clinical pathology and neuropathology at the Departments of Neuropathology and Experimental Brain Research, Hamburg, the Department of Pathology, Hamburg, and at the Brigham and Women’s and Children’s Hospital, Boston. From 1994 to 1999, he completed residency training in Anatomic Pathology and a Molecular Pathology Fellowship at the Laboratory of Pathology,...

Dr. Alexander Vortmeyer graduated from Hamburg University Medical School in 1987. From 1988 to 1994, he was trained in academic and clinical pathology and neuropathology at the Departments of Neuropathology and Experimental Brain Research, Hamburg, the Department of Pathology, Hamburg, and at the Brigham and Women’s and Children’s Hospital, Boston. From 1994 to 1999, he completed residency training in Anatomic Pathology and a Molecular Pathology Fellowship at the Laboratory of Pathology, National Cancer Institute, Bethesda. At the same time, he performed pioneering studies using tissue microdissection and genetic analysis with Drs. Liotta and Zhuang.

In 1999, Dr. Vortmeyer was appointed Acting Director of Neuropathology at the National Institute of Neurological Disorders and Stroke (NINDS). At NINDS, he further developed and promoted tissue-based research in collaboration with numerous basic and clinical laboratories within NINDS, NCI, and the National Human Genome Research Institute (NHGRI).

In 2008, Dr. Vortmeyer joined the Yale Department of Pathology as Director of the Neuroapathology Program. He is interested in principles of earliest tumorigenesis and the application of new technologies in studies on neoplastic and degenerative neurologic disease.

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Members

Bai, Yalai

Associate Research Scientist in Pathology

Brooks, Amos

Histotechnologist

Charette, Lori A

Laboratory Director Developmental Histology

Johnson, Laura A

Laboratory Assistant

McGuire, John

Research Assistant

Research Interests:Quantification of proteins, development of prognostic and predictive biomarker assays, immunohistochemistry,

Melucci, Rebecca

Histotechnologist

Neumeister, Veronique

Associate Research Scientist in Pathology

Research Interests:early breast carcinogenesis, development of companion diagnostic tests, in situ quantification of proteins and nucleic acids, development of prognostic and predictive biomarker signatures for breast and other cancers

Salemme, Deirdre Hynes

Histotechnologist