The problem of stromal contamination for tumor classification

alt text

Many biomarker and molecular tests are based on extraction methods of tissue lysates. This leads to loss of spatial information and “contamination” of areas of interest with unwanted cells and tissue types.

alt text

IDC=Infiltrating Ductal Carcinoma/

DCIS=Ductal Carcinoma

In Situ/

SRA= Stromal Rich

Areas

Value of contextual measurement of proteins and nucleic acids
alt text

Reproducibility and observer independence of 

automated quantification