A classic issue in biology is validation of a new concept on actual human tissue. A frequent problem is there is not enough tissue, either in amount or case number, to complete the analysis. This chronic shortage of tissue is partly due to the fact that the initial sampling is typically done by a pathologist whose primary goal is to provide a diagnostic consultation, not material for future experimentation. The difficulty of working with human tissue is further complicated by increasingly stringent guidelines regarding obtaining informed consent for its use. Thus, when tissue is obtained, it should be optimally managed to maximize its value. Tissue microarray represents a mechanism for highly effective use of this scarce resource.
Also see the Advantages page