Translational Research Program

In the era of precision medicine, rapid translation of basic scientific discoveries to patient management has become increasingly crucial to clinical practice, particularly modern oncology. Through tissue analysis, and in collaboration with various clinical specialties, pathologists are at a unique position to interact with both basic scientists and clinical investigators to facilitate timely and efficient translation of major scientific findings to disease prevention, diagnosis, treatment and prognostication.

Armed with state-of-the-art technology, Yale Pathology has various translational subspecialty programs involving active collaborations with basic scientists and clinicians within and outside of the department. Pathology residents and subspecialty fellows are also an integral part of these academic endeavors and are encouraged to make their own contributions to translational research as part of their clinical training experience.

Translational Research Labs

braddock 

Braddock Lab

In our laboratory we study the pathophysiology of benign and malignant hematologic disorders using biochemical and biophysical methods.

kluger

Kluger Lab
Developing computational methodologies for analyzing high throughput biomedical data

krauthammer

Krauthammer Lab
Research in translational informatics with a focus on cancer genetics

madri

Madri Lab
-Neural stem cell responses to injury
- Roles of cell-cell and cell-ECM molecules in repair

min

Min Lab
My lab has extensively employed biochemical, cell biological and mouse genetic approaches to define the critical molecules mediating vascular development, remodeling and repair related to human diseases such as vascular malformation, stroke, atherosclerosis, graft transplant rejection and tumor metastasis. We are testing small molecule, gene therapy and cell-based approaches to treat these diseases in mouse models.

nguyen

Nguyen Lab
Metastasis; Tissue development; Lung cancer; Cancer genomics; Tumor microenvironment.

politi

Politi Lab
My laboratory studies mechanisms of lung tumorigenesis, in particular, the molecular features of tumors that determine response and resistance to targeted drugs.

rimm

Rimm Lab
Development and use of quantitative approaches to pathology and assay development to classify tumors or predict invasion, metastasis or response to cancer therapy

rose

Rose Lab
The Rose laboratory focuses on developing new approaches to vaccines that will provide long-term protection against viral and bacterial diseases.

vortmeyer

Vortmeyer Lab
-Early tumorigenesis in tumor suppressor gene disorders
-Tissue degradation markers
- Radiation-induced encephalopathy

yan

Yan Lab 
Cancer Epigenetics and Stem Cell Biology.