Fundamental Research Program
Breakthroughs in the basic sciences often provide the conceptual and technological advances necessary to improve human medicine. Our faculty members have made important discoveries across multiple fundamental disciplines. Active areas of basic research in the department range from signal transduction, genomics, and bioinformatics to virology, cell metabolism, and tissue development.
Fundamental Research Labs
In our laboratory we study the pathophysiology of benign and malignant hematologic disorders using biochemical and biophysical methods.
Our laboratory uses genetic approaches to investigate mechanisms that regulate systemic iron balance in normal physiology and to understand how disruption of these mechanisms contributes to the pathogenesis of clinical disorders of iron metabolism.
The goal of the Katz laboratory is to selectively control the cell death machinery for therapeutic benefit. We use a multidisciplinary approach to study select pro-apoptotic BCL-2 family proteins.
We are a computational immunology lab. Our work combines techniques from dynamic modeling, systems biology and bioinformatics to better understand the immune response.
Developing computational methodologies for analyzing high throughput biomedical data
My laboratory is also focused on elucidating the mechanism through which the endogenous inhibitor of angiogenesis TSP-2 limits angiogenesis and arteriogenesis.
My lab has extensively employed biochemical, cell biological and mouse genetic approaches to define the critical molecules mediating vascular development, remodeling and repair related to human diseases such as vascular malformation, stroke, atherosclerosis, graft transplant rejection and tumor metastasis. We are testing small molecule, gene therapy and cell-based approaches to treat these diseases in mouse models.
The research focus of my lab is in tubular injury repair, progression of diabetic nephropathy and aldosterone-dependent renal fibrosis. We are especially interested how renal pericytes orchestrate the cytokine action that mediates tubular epithelial cell repair. We have recently described a medullary pericyte population that shows a significant effect on tubular cell migration and proliferation. Furthermore, we are interested in the aldosterone-dependent signaling and transcription pathways that drive fibronectin and collagen expression in renal fibroblasts. Another project in the lab is the investigation of the molecular and genetic mechanisms of fibrosis progression in diabetic nephropathy.
Our laboratory focuses our studies on understanding the principles of cell membrane biogenesis and order. Specifically, we investigate the mechanisms of the spectrin-based scaffold in hematological and neurological disease.
Metastasis; Tissue development; Lung cancer; Cancer genomics; Tumor microenvironment.
My laboratory studies mechanisms of lung tumorigenesis, in particular, the molecular features of tumors that determine response and resistance to targeted drugs.
Virus-host interactions, innate immunity, vaccine development, oncolytic viruses
The Rose laboratory focuses on developing new approaches to vaccines that will provide long-term protection against viral and bacterial diseases.
Mechanism of mitochondrial gene expression and the role of mitochondria in disease and aging.
The focus of my laboratory is to identify and characterize the regulators of tumor initiation and progression. To do so, we employ biochemical, genetic, functional genomics, pharmacological and clinical pathology-based approaches. The long-term goal is to translate our basic cancer cell biology findings into clinically effective and durable therapies for cancer treatment.
Cancer Epigenetics and Stem Cell Biology.