Fundamental Research Program

Breakthroughs in the basic sciences often provide the conceptual and technological advances necessary to improve human medicine.  Our faculty members have made important discoveries across multiple fundamental disciplines. Active areas of basic research in the department range from signal transduction, genomics, and bioinformatics to virology, cell metabolism, and tissue development.

Fundamental Research Labs

In the Braddock Lab we study the pathophysiology of benign and malignant hematologic disorders using biochemical and biophysical methods.
In the Finberg Lab, we use genetic approaches to investigate mechanisms that regulate systemic iron balance in normal physiology and to understand how disruption of these mechanisms contributes to the pathogenesis of clinical disorders of iron metabolism.
The goal of the Katz Lab is to selectively control the cell death machinery for therapeutic benefit. We use a multidisciplinary approach to study select pro-apoptotic BCL-2 family proteins.
The Kleinstein Lab is a computational immunology lab. Our work combines techniques from dynamic modeling, systems biology and bioinformatics to better understand the immune response.
The Kluger Lab concentrates on developing computational methodologies for analyzing high throughput biomedical data.
The Kyriakides Lab is focused on elucidating the mechanism through which the endogenous inhibitor of angiogenesis TSP-2 limits angiogenesis and arteriogenesis.
In the Madri Lab we investigate neural stem cell responses to injury and roles of cell-cell and cell-ECM molecules in repair.
The Min Lab has extensively employed biochemical, cell biological and mouse genetic approaches to define the critical molecules mediating vascular development, remodeling and repair related to human diseases such as vascular malformation, stroke, atherosclerosis, graft transplant rejection and tumor metastasis. We are testing small molecule, gene therapy and cell-based approaches to treat these diseases in mouse models.
The research focus of the Moeckel Lab is in tubular injury repair, progression of diabetic nephropathy and aldosterone-dependent renal fibrosis. We are especially interested how renal pericytes orchestrate the cytokine action that mediates tubular epithelial cell repair. We have recently described a medullary pericyte population that shows a significant effect on tubular cell migration and proliferation. Furthermore, we are interested in the aldosterone-dependent signaling and transcription pathways that drive fibronectin and collagen expression in renal fibroblasts. Another project in the lab is the investigation of the molecular and genetic mechanisms of fibrosis progression in diabetic nephropathy.
The Morrow Lab focuses our studies on understanding the principles of cell membrane biogenesis and order. Specifically, we investigate the mechanisms of the spectrin-based scaffold in hematological and neurological disease.
The Nguyen Lab does investigation in the following areas: Metastasis; Tissue development; Lung cancer; Cancer genomics; Tumor microenvironment.
In the Politi Lab, we study mechanisms of lung tumorigenesis, in particular, the molecular features of tumors that determine response and resistance to targeted drugs.
The Rose Lab focuses on developing new approaches to vaccines that will provide long-term protection against viral and bacterial diseases.
The Shadel Lab studies the mechanism of mitochondrial gene expression and the role of mitochondria in disease and aging.
Research in the Sklar Lab generally concerns the molecular biology of human disease, particularly in the areas of the molecular genetics of cancer, lymphocyte biology, endometrial function, and the development of molecular methods for disease diagnosis. The research is of both a basic and translational nature.
The Stern Lab investigates the cancer-causing processes of genetic and epigenetic changes that alter hormone-regulated signal transduction pathways, leading to growth dysregulation, and that alter protective responses to DNA damage, leading to genomic instability.
The Vortmeyer Lab focuses on investigating early tumorigenesis in tumor suppressor gene disorders, tissue degradation markers, and radiation-induced encephalopathy.
The focus of the Wajapeyee Lab is to identify and characterize the regulators of tumor initiation and progression. To do so, we employ biochemical, genetic, functional genomics, pharmacological and clinical pathology-based approaches. The long-term goal is to translate our basic cancer cell biology findings into clinically effective and durable therapies for cancer treatment.
The Yan Lab studies cancer epigenetics and stem cell biology. We are interested in understanding how epigenetic aberrations cause cancer and other human diseases. In particular, we focus on the roles and regulatory mechanisms of histone demethylases from the JARID1/KDM5 protein family.