Yunhua (Cindy) Bao MD

Associate Research Scientist in Neurobiology

Research Interests

iPSCs, ESCs; Differentiation; Patients; Myogenesis; Transgenic

Research Summary

Modeling congenital muscular dystrophy via induced pluripotent stem cells.

Extensive Research Description

  • My past work was to creating transgenic mouse models to study the prostate cell populations and characterize the adult stem cell in prostate epithelial cell compartment. My current project is to modeling congenital muscular dystrophy via induced pluripotent stem cells. We focus onX-linked myotubular myopathy (XLMTM), a severe form of CMDs. Although thedeletion or point mutation of MTM1gene has been implicated in the etiology of this disorder, to date itspathogenesis is poorly understood. Recent progress in our understandingof human induced pluripotent stem cells (iPSCs) opened a new avenue formodeling human diseases. This dynamic recapitulation of disease process willhelp gain insight into disease pathogenesis and might potentially aid infinding specific therapeutic interventions such as gene-based therapy. Inthis study we are aimed to generate the iPSCs from somatic cells of patientswith XLMTM as well as to induce differentiation of these patient specific iPSCsinto functional myocytes.

Selected Publications

  • 1. Bao Y, Huttner AJ. Modeling neurogenetic disorders via induced pluripotent stem cells - a novel alternative for pathology. Modern Pathology 2011; 24 (suppl 1):390A
  • 2. Peng W, Bao Y, Sawicki JA. Epithelial cell-targeted transgene expression enables isolation of cyan fluorescent protein (CFP) - expressing prostate stem/progenitor cells. The Journal of Transgenic Research 2011; 20:1073-1086.
  • 3. Huang Y, Bao Y, Peng W, Goldberg M, Love K, Mumcrot D, Langer R, Anderson D, Sawicki JA. Claudin-3 gene silencing with small interfering RNA suppresses ovarian tumor growth and metastasis. The Proceedings of the National Academy of Sciences 2009; 106:3426-3430.
  • 4. Peng W, Anderson D, Bao Y, Padera Jr R, Langer R, Sawicki JA. Nanoparticulate delivery of suicide DNA to murine prostate and prostate tumors. Prostate 2007; 67:855-862.
  • 5. Bao Y, Peng W, Verbitsky A, Chen J, Wu L, Rauren KA, Sawicki JA. Human Coxsackie adenovirus receptor (CAR) expression in transgenic mouse prostate tumor enhances adenoviral delivery of genes. Prostate 2005; 64:401-407.

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