Jie Li MD, PhD

Research Scientist in Pathology

Research Interests

Molecular Neuro-Oncology; Proteomics; Selective tissue dissection; Neurosurgery; Genomics; Therapeutic targets; Biomarkers; Brain tumors; Human specimen; Microdissection


Research Summary

Searching new targets for cancer therapy via using combined high-tech tools.

Extensive Research Description

Translational Research: discover bio-markers, therapeutic targets via selective tissue dissection and proteomics using clinical specimens.
Brain tumor therapy: use combined gene therapy, immuno-therapy and newly developed strategy like small molecules.
Technology improvement and invention: design and validate new technical improvement, crossing the fields of proteomics, microdissection, genomics, tissue array, neurosurgical instruments, drug delivery, etc. Collaboration is extremely welcome and considered as a MUST!


Selected Publications

  • Vortmeyer AO, Falke EA, Gläsker S, Li J, Oldfield EH. Nervous system involvement in von Hippel-Lindau disease: pathology and mechanisms. Acta Neuropathol. 2013 Feb 12. [Epub ahead of print]
  • Clark VE, Erson-Omay EZ, Serin A, Yin J, Cotney J, Ozduman K, et al. Genomic Analysis of Non-NF2 Meningiomas Reveals Mutations in TRAF7, KLF4, AKT1, and SMO. Science. 2013
  • Lu Y, Chen JJ, Mu L, Xue Q, Wu Y, Wu PH, et al. High-throughput secretomic analysis of single cells to assess functional cellular heterogeneity. Anal Chem. 2013
  • Li J, Kil C, Considine K, Smarkucki B, Stankewich MC, Balgley B, et al. Intrinsic indicators for specimen degradation. Lab Invest. 2012
  • Ma X, Wang L, Tang J, Li J, Ganins P. SPOC domain of mint protein induces hematopoietic differentiation via Bmp4/Smad5 pathway. American Journal of Molecular Biology. 2012;2:304-17
  • Lee SK, Kim GS, Wu Y, Kim DJ, Lu Y, Kwak M, et al. Nanowire substrate-based laser scanning cytometry for quantitation of circulating tumor cells. Nano letters. 2012;12:2697-704
  • Glasker S, Vortmeyer AO, Lafferty AR, Hofman PL, Li J, Weil RJ, et al. Hereditary pituitary hyperplasia with infantile gigantism. J Clin Endocrinol Metab. 2011;96:E2078-87.
  • Zhuang Z, Qi M, Li J, Okamoto H, Xu DS, Iyer RR, Lu J, Yang C, Weil RJ, Vortmeyer A, Lonser RR. Proteomic identification of glutamine synthetase as a differential marker for oligodendrogliomas and astrocytomas. J Neurosurg. 2011 Jun 17. [Epub ahead of print] PMID: 21682567
  • Tsai-Morris CH, Sheng Y, Gutti R, Li J, Pickel J, Dufau ML. Gonadotropin-regulated testicular RNA helicase (GRTH/DDX25) gene: cell-specific expression and transcriptional regulation by androgen in transgenic mouse testis. J Cell Biochem. 2010;109:1142-7.
  • Shively SB, Falke EA, Li J, Tran MG, Thompson ER, Maxwell PH, Roessler E, Oldfield EH, Lonser RR, Vortmeyer AO. Developmentally arrested structures preceding cerebellar tumors in von Hippel-Lindau disease. Mod Pathol. 2011 Aug;24(8):1023-30. doi: 10.1038/modpathol.2011.61. Epub 2011 Apr 15. PMID: 21499240

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