Jie Li MD, PhD
Research Scientist in Pathology
Research Interests
Molecular Neuro-Oncology; Proteomics; Selective tissue dissection; Neurosurgery; Genomics; Therapeutic targets; Biomarkers; Brain tumors; Human specimen; Microdissection
Research Summary
Searching new targets for cancer therapy via using combined high-tech tools.
Extensive Research Description
Translational Research: discover bio-markers, therapeutic targets via selective tissue dissection and proteomics using clinical specimens.
Brain tumor therapy: use combined gene therapy, immuno-therapy and newly developed strategy like small molecules.
Technology improvement and invention: design and validate new technical improvement, crossing the fields of proteomics, microdissection, genomics, tissue array, neurosurgical instruments, drug delivery, etc. Collaboration is extremely welcome and considered as a MUST!
Selected Publications
- Vortmeyer AO, Falke EA, Gläsker S, Li J, Oldfield EH. Nervous system involvement in von Hippel-Lindau disease: pathology and mechanisms. Acta Neuropathol. 2013 Feb 12. [Epub ahead of print]
- Clark VE, Erson-Omay EZ, Serin A, Yin J, Cotney J, Ozduman K, et al. Genomic Analysis of Non-NF2 Meningiomas Reveals Mutations in TRAF7, KLF4, AKT1, and SMO. Science. 2013
- Lu Y, Chen JJ, Mu L, Xue Q, Wu Y, Wu PH, et al. High-throughput secretomic analysis of single cells to assess functional cellular heterogeneity. Anal Chem. 2013
- Li J, Kil C, Considine K, Smarkucki B, Stankewich MC, Balgley B, et al. Intrinsic indicators for specimen degradation. Lab Invest. 2012
- Ma X, Wang L, Tang J, Li J, Ganins P. SPOC domain of mint protein induces hematopoietic differentiation via Bmp4/Smad5 pathway. American Journal of Molecular Biology. 2012;2:304-17
- Lee SK, Kim GS, Wu Y, Kim DJ, Lu Y, Kwak M, et al. Nanowire substrate-based laser scanning cytometry for quantitation of circulating tumor cells. Nano letters. 2012;12:2697-704
- Glasker S, Vortmeyer AO, Lafferty AR, Hofman PL, Li J, Weil RJ, et al. Hereditary pituitary hyperplasia with infantile gigantism. J Clin Endocrinol Metab. 2011;96:E2078-87.
- Zhuang Z, Qi M, Li J, Okamoto H, Xu DS, Iyer RR, Lu J, Yang C, Weil RJ, Vortmeyer A, Lonser RR. Proteomic identification of glutamine synthetase as a differential marker for oligodendrogliomas and astrocytomas. J Neurosurg. 2011 Jun 17. [Epub ahead of print] PMID: 21682567
- Tsai-Morris CH, Sheng Y, Gutti R, Li J, Pickel J, Dufau ML. Gonadotropin-regulated testicular RNA helicase (GRTH/DDX25) gene: cell-specific expression and transcriptional regulation by androgen in transgenic mouse testis. J Cell Biochem. 2010;109:1142-7.
- Shively SB, Falke EA, Li J, Tran MG, Thompson ER, Maxwell PH, Roessler E, Oldfield EH, Lonser RR, Vortmeyer AO. Developmentally arrested structures preceding cerebellar tumors in von Hippel-Lindau disease. Mod Pathol. 2011 Aug;24(8):1023-30. doi: 10.1038/modpathol.2011.61. Epub 2011 Apr 15. PMID: 21499240
Selected Publications
- Vortmeyer AO, Falke EA, Gläsker S, Li J, Oldfield EH. Nervous system involvement in von Hippel-Lindau disease: pathology and mechanisms. Acta Neuropathol. 2013 Feb 12. [Epub ahead of print]
- Clark VE, Erson-Omay EZ, Serin A, Yin J, Cotney J, Ozduman K, et al. Genomic Analysis of Non-NF2 Meningiomas Reveals Mutations in TRAF7, KLF4, AKT1, and SMO. Science. 2013
- Lu Y, Chen JJ, Mu L, Xue Q, Wu Y, Wu PH, et al. High-throughput secretomic analysis of single cells to assess functional cellular heterogeneity. Anal Chem. 2013
- Li J, Kil C, Considine K, Smarkucki B, Stankewich MC, Balgley B, et al. Intrinsic indicators for specimen degradation. Lab Invest. 2012
- Ma X, Wang L, Tang J, Li J, Ganins P. SPOC domain of mint protein induces hematopoietic differentiation via Bmp4/Smad5 pathway. American Journal of Molecular Biology. 2012;2:304-17
- Lee SK, Kim GS, Wu Y, Kim DJ, Lu Y, Kwak M, et al. Nanowire substrate-based laser scanning cytometry for quantitation of circulating tumor cells. Nano letters. 2012;12:2697-704
- Glasker S, Vortmeyer AO, Lafferty AR, Hofman PL, Li J, Weil RJ, et al. Hereditary pituitary hyperplasia with infantile gigantism. J Clin Endocrinol Metab. 2011;96:E2078-87.
- Zhuang Z, Qi M, Li J, Okamoto H, Xu DS, Iyer RR, Lu J, Yang C, Weil RJ, Vortmeyer A, Lonser RR. Proteomic identification of glutamine synthetase as a differential marker for oligodendrogliomas and astrocytomas. J Neurosurg. 2011 Jun 17. [Epub ahead of print] PMID: 21682567
- Tsai-Morris CH, Sheng Y, Gutti R, Li J, Pickel J, Dufau ML. Gonadotropin-regulated testicular RNA helicase (GRTH/DDX25) gene: cell-specific expression and transcriptional regulation by androgen in transgenic mouse testis. J Cell Biochem. 2010;109:1142-7.
- Shively SB, Falke EA, Li J, Tran MG, Thompson ER, Maxwell PH, Roessler E, Oldfield EH, Lonser RR, Vortmeyer AO. Developmentally arrested structures preceding cerebellar tumors in von Hippel-Lindau disease. Mod Pathol. 2011 Aug;24(8):1023-30. doi: 10.1038/modpathol.2011.61. Epub 2011 Apr 15. PMID: 21499240
- Helgager J, Li J, Lubensky IA, Lonser R, Zhuang Z. Troglitazone reduces glyoxalase I protein expression in glioma and potentiates the effects of chemotherapeutic agents. J Oncol. 2010;2010:373491.
- Li J, Yin C, Okamoto H, Mushlin H, Balgley BM, Lee CS, Yuan K, Ikejiri B, Glasker S, Vortmeyer AO, Oldfield EH, Weil RJ, Zhuang Z. Identification of a novel proliferation-related protein, WHSC1 4a, in human gliomas. Neuro Oncol. 2008 Feb10(1):45-51. Epub 2008 Jan 8. Erratum in: Neuro Oncol. 2008 Apr10(2):231.
