Jung Hwan Kim, MD

Professor Emeritus of and Senior Research Scientist in Pathology

Research Organizations

Pathology

Neural Transplant and Neurobehavior Program

Extensive Research Description

Hippocampal sclerosis (neuronal loss and gliosis) plays a complicated role in epilepsy: hippocampal sclerosis occurs due to epilepsy, but, in turn, the sclerotic hippocampus appears to be responsible for epileptogenesis. We are looking into the role of hippocampal neurons and glial cells in epilepy through neuronal and glial density studies in surgically resected hippocampi from intractable epilepsy patients. My second research interest is the role of calpains in CNS degenerative disorders, epilepsy and AIDS. All three conditions just mentioned are believed to have neuronal damages, at least in part, due to excitotoxicity, which may acitivate calpains, a family of Ca++ dependant proteases. Calpains, once activated, cleave spectrin, generating the spectrin breakdown product (BDP), and involvement of calpains is determined by detecting spectrin BDP in the CNS tissue.

Selected Publications

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Contact Info

Jung Hwan Kim, MD
Office Location
Department of PathologyLauder Hall
310 Cedar Street, Ste LH 219B

New Haven, CT 06510
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Mailing Address
310 Cedar Street
PO Box 208023

New Haven, CT 06520-8023

Autopsy Pathology

Surgical Pathology