Jose Costa MD, FACP

Professor of Pathology, of Medicine (Medical Oncology) and of Orthopaedics and Rehabilitation; Director, Translational Diagnostics; Director, Musculoskeletal Tumor Program

Departments & Organizations

Yale Combined Program in the Biological and Biomedical Sciences (BBS): Molecular Medicine, Pharmacology, and Physiology

Yale Medical Group

Office of Student ResearchCancer Center, Yale: Cancer Genetics & Genomics; Sarcoma Oncology ProgramPathology: Surgical Pathology: Bone and Soft-tissue Pathology, Pediatric Pathology; Molecular Diagnostics; ExPath | Orthopaedics and RehabilitationMolecular DiagnosticsGene Regulation and Functional Genomics

Research Interests

Oncology; Carcinogenesis; Tumor development and progression; Advanced diagnostics; Molecular diagnostics; Diagnosed genetic alterations in tumors; Cancer risk detection by mutational load distribution analysis more...


  • M.D., University of Barcelona, 1967

Selected Publications

  • Costa, J., Gonzalez-Garcia, I., and Sole, R. (2006). Spatial Dynamics in Cancer, in Complex Systems Science in Biomedicine (Deisboeck, T.S., and Kresh, J.Y.), Chapter 6.2, pp. 557-572.
  • Lage, J.M., et al. (2003). Whole genome analysis of genetic alterations in small DNA samples using hyperbranched strand displacement amplification and array-CGH. Genome Res. 13:294-307.
  • Tallini G, Ghossein RA, Emanuel J, Gill J, Kinder B, Dimich AB, Costa J, Robbins R, Burrow GN, Rosai J. (1998) Detection of thyroglobulin, thyroid peroxidase, and RET/PTC1 mRNA transcripts in the peripheral blood of patients with thyroid disease. Journal of Clinical Pathology, Vol 16(3): 1158-1166.



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