Demetrios Braddock MD, PhD
Associate Professor of Pathology
Structural biology; Hematopathology; Genitourinary Pathology
- Structural biology of protein complexes implicated in the pathogenesis of cancer
- Genetic transcription
Extensive Research Description
My group is primarily interested in biochemical and structural aspects of oncogensis and blood disorders. Prior work involved determining structures of c-myc transcription factors and developing small molecule inhibitors against proteins involved in tumor metastasis. We are currently characterizing a vascular endothelial enzyme that promotes platelet aggregation by locally increasing ADP concentrations at the site of platelet degranulation.
- Albright, R.A., Chang, W.C., Robert, D., Ornstein, D.L., Cao, W., Redick, M.E., Young, J.I., De La Cruz, E. M., Braddock, D.T., “NPP4 is a procoagulant enzyme on the surface of vascular endothelium” Blood, (2012) 120:4432-4440.
- Saunders, L. P., Wenxiang Cao, W., Chang, W. C., Albright, W.A., Demetrios T. Braddock, D. T.,* De La Cruz, E.M.*, “Kinetic Analysis of Autotaxin Reveals Substrate-specific Catalytic Pathways and a Mechanism for Lysophosphatidic Acid Distribution” (2011) Journal of Biological Chemistry, Aug 26;286(34):30130-41.
- Braddock, D.T. “Autotaxin and lipid signaling pathways as anticancer targets” Current Opinion in Investigational Drugs (2010) 11:629-37.
- Crichlow, G. V., Zhou, H., Yang, Y., Hsiao, H-H, Frederick, K. B., Debrosse, M., Yang, Y., Folta-Stogniew, E. J., Chung., H-J, Fan, C., De La Cruz, E. M., Levens, D.L., Lolis E., and Braddock, D.T. Dimerization of FIR upon FUSE DNA binding suggests a mechanism of c-myc inhibition. (2008) EMBO, 27 277-289