Molecular Cytogenetics Laboratory (Genetics)
- Dr. Peining Li, Director
Cytogenetics is now an integral diagnostic and prognostic tool in various branches of medicine (e.g. oncology, pediatrics, cardiology, neurology, and internal medicine). The number of syndromes identified as associated with chromosome abnormalities has increased from less than a dozen in the 1960s to over 400 today. More recently, cancer cytogenetics has provided valuable diagnostic and prognostic information for tumors of hematopoietic and lymphoid tissues. The cytogenetics laboratory at Yale University School of Medicine has been updated and staffed and now offers a full range of services for clinicians and researchers from Yale and beyond.
The cytogenetics laboratory services include routine and specialized chromosome karyotype analysis, fluorescence in situ hybridization (FISH) and genome-wide array comparative genomic hybridization (aCGH), and collaborative research services. Types of specimens processed include blood, amniotic fluids, chorionic villus, products of conception, bone marrow, skin, solid tumors, and many others. Our laboratory provides fast turn-around time and competitive prices.
Additional Resident Duties and Responsibilities on the Cytogenetics Rotation
- Become familiar with analytical cytogenetic techniques, nomenclature, and counseling
- Gain experience in human chromosome G-band techniques and chromosome identification
- Learn FISH and aCGH techniques.
- Interpret and report numerical and structural chromosome abnormalities
Additional Goals and Objectives for the Molecular Cytogenetics Rotation
- Perform karyotyping and FISH imaging for selected abnormal cases
- Interpret test results from karyotyping, FISH, and aCGH analyses
- Become proficient in presenting cases at laboratory rounds and correlation conferences