Genetics; Carcinoma, Hepatocellular; Lung Neoplasms; Melanoma; Pancreatic Neoplasms; Pathology; Disease Progression; Carcinogenesis; Phenomena and Processes
Obesity Research Working Group
Cancer is a complex disease and typically involves multiple gene-specific and global genetic and epigenetic changes in human genome. The major class of genes that has been causally linked to the process of tumorigenesis is tumor suppressors, which acts as a “breaks” and oncogenes, which functions as “accelerators” and typically promotes cancer. Recently, non-coding RNAs such as miRNAs and long non-coding RNAs are also linked to cancer wherein they can either promote or inhibit cancer cell growth. The focus of our lab is to understand the mechanisms of genetic and epigenetic regulation of cancer initiation and progression and translating this understanding for early detection and treatment of human cancers. We use melanoma, pancreatic cancer, lung cancer, hepatocellular carcinoma and hematological malignancies as model systems to study mechanism of tumor initiation and progression.
Specialized Terms: Genetic and epigenetic mechanisms of cancer initiation and progression
MELK promotes melanoma growth by stimulating the NF-kB pathway
Radoslav Janostiak, Navin Rauniyar, TuKiet T. Lam, Jianhong Ou, Lihua J. Zhu, Michael R. Green, and Narendra Wajapeyee, Cell Reports, 2017 Dec 5;21(10):2829-2841.
Paraoxonase 2 facilitates pancreatic cancer growth and metastasis by stimulating GLUT1-mediated glucose transport.
Arvindhan Nagarajan, Shaillay Kumar Dogra, Lisha Sun, Neeru Gandotra, Thuy Ho, Guoping Cai, Gary Cline, Robert A. Cowles, Priti Kumar and Narendra Wajapeyee. Molecular Cell. 2017 Aug 17;67(4):685-701.e6. doi: 10.1016/j.molcel.2017.07.014. Epub 2017 Aug 10.
Serine hydroxymethyl transferase 1 stimulates pro-oncogenic cytokine expression through sialic acid to promote ovarian cancer tumor growth and progression.
Gupta R, Yang Q, Dogra SK, Wajapeyee N. Oncogene. 2017 Jul 13;36(28):4014-4024. doi: 10.1038/onc.2017.37. Epub 2017 Mar 13.
Interferon alpha-inducible protein 6 regulates NRASQ61K-induced melanomagenesis and growth.
Gupta R, Forloni M, Bisserier M, Dogra SK, Yang Q, Wajapeyee N. Elife. 2016 Sep 8;5. pii: e16432. doi: 10.7554/eLife.16432.
MARCH1 regulates insulin sensitivity by controlling cell surface insulin receptor levels.
Nagarajan A, Petersen MC, Nasiri AR, Butrico G, Fung A, Ruan HB, Kursawe R, Caprio S, Thibodeau J, Bourgeois-Daigneault MC, Sun L, Gao G, Bhanot S, Jurczak MJ, Green MR, Shulman GI, Wajapeyee N. Nature Communication. 2016 Aug 31;7:12639. doi: 10.1038/ncomms12639.
Oncogenic EGFR Represses the TET1 DNA Demethylase to Induce Silencing of Tumor Suppressors in Cancer Cells.
Forloni M, Gupta R, Nagarajan A, Sun LS, Dong Y, Pirazzoli V, Toki M, Wurtz A, Melnick MA, Kobayashi S, Homer RJ, Rimm DL, Gettinger SJ, Politi K, Dogra SK, Wajapeyee N. Cell Reports 2016 Jul 12;16(2):457-471. doi: 10.1016/j.celrep.2016.05.087. Epub 2016 Jun 23.
LKB1 preserves genome integrity by stimulating BRCA1 expression.
Gupta R, Liu AY, Glazer PM, Wajapeyee N. Nucleic Acids Res. 2015 Jan;43(1):259-71. doi: 10.1093/nar/gku1294. Epub 2014 Dec 8.
TRIM37 is a new histone H2A ubiquitin ligase and breast cancer oncoprotein.
Bhatnagar S, Gazin C, Chamberlain L, Ou J, Zhu X, Tushir JS, Virbasius CM, Lin L, Zhu LJ, Wajapeyee N, Green MR. Nature. 2014 Dec 4;516(7529):116-20. doi: 10.1038/nature13955. Epub 2014 Nov 24.