Graduate Courses (FAS)

PATH 200: Molecular and Genomic Mechanisms of Disease

This is predominantly a seminar course which covers aspects of the fundamental molecular and cellular mechanisms underlying various human diseases in the context of various clinical scenarios. The objective is to highlight advances in genomic and molecular medicine as they relate to understanding the pathogenesis of disease and the formulation of therapies. Various times. There are a few lectures on autopsy pathology and one lecture on bioinformatics. The course is only open to medical students.

PATH 600: Pathological Basis of Human Disease

Fundamental principles underlying the pathological alterations in function and structure that constitute the reaction of the organism to injury. Pathology of diseases involving neoplasia and special organs and systems. Correlation of the clinical and anatomical manifestations is emphasized. For EPH graduate students and MSTP students who are required to take PATH 100 for graduate credit.

PATH 616: Autopsy Pathology

The course will provide participation in the autopsy service with house staff in pathology. The course will cover proper performance of the autopsy including dissection, documentation and reporting, presentation of autopsy findings and communication of medical opinions formed from the autopsy. The work will include involvement in dissection of cases, review of gross pathology, submission of sections for histology, review of microscopic slides, preparation of reports of findings and involvement in investigative procedures related to necropsy material.

Opportunities exist for correlation studies with previous biopsies, and clinical investigative and cell biologic techniques in relation to necropsy material and attendance. Six weeks minimum, enrollment limited to two students.

PATH 617: Anatomic Pathology Elective

The department offers an elective to medical students in the third and fourth years that provides a broad experience in general diagnostic techniques. Students have opportunities to participate in surgical pathology, cytology (including fine-needle aspiration), and autopsy. A daily diagnostic conference is scheduled for both residents and students, and an additional two hours of conference are provided each week exclusively for the students. In addition to direct responsibilities in the handling of the cases, the student has the opportunity to apply the special techniques of electron microscopy, immunohistochemistry, and flow cytometry. A minimum of four weeks is suggested for this elective. Five students are accommodated every four to six weeks.

PATH 618b: Clinical and Pathologic Correlates in Renal Disease

A series of clinical pathologic conferences designed to illustrate clinicopathologic correlates in renal disease. At each session, one student acts as clinician and another as pathologist in the evaluation and discussion of case material from autopsies or renal biopsies. Discussions are informal, but require preparation in advance and all participants are expected to contribute in each session. One two-hour session per week for six weeks. Given once in spring term. Limited to twelve students.

PATH 620a and b: Laboratory Rotations in Experimental Pathology

Laboratory rotations for first-year graduate students.

PATH 630b/ENAS 535b: Biomaterial-Tissue Interactions

The course addresses the interactions between tissues and biomaterials, with an emphasis on the importance of molecular- and cellular-level events in dictating the performance and longevity of clinically relevant devices. In addition, specific areas such as biomaterials for tissue engineering and the importance of stem/progenitor cells, and biomaterial-mediated gene and drug delivery are addressed.

PATH 650b: Cellular and Molecular Biology of Cancer

A comprehensive survey of cancer research from the cellular to the clinical level. The relation of cancer to intracellular and intercellular regulation of cell proliferation is emphasized, as are animal models for cancer research. Background in molecular genetics and cell biology is assumed. Open to advanced undergraduates with permission of the organizers.

PATH 660/C&MP 650/PHAR 580: Ethics

Organized to foster discussion, the course is taught by faculty in the Pharmacology, Pathology, and Physiology departments and two or three senior graduate students. Each session is based on case studies from primary literature, reviews, and two texts: Francis Macrina’s Scientific Integrity and Kathy Barker’s At the Bench. Each week, students are required to submit a reaction paper discussing the reading assignment. Students take turns leading the class discussion; a final short paper on a hot topic in bioethics is required.

Pathology 670b: Biological Mechanisms of Reaction to Injury

An introduction to human biology and disease as a manifestation of reaction to injury. Topics include organ structure and function, cell injury, circulatory and inflammatory responses, disordered physiology, and neoplasia.

PATH 680a/C&MP 630a/PHAR 502a: Seminar in Molecular Medicine, Pharmacology, and Physiology

Readings and discussion on a diverse range of current topics in molecular medicine, pharmacology, and physiology. The class emphasizes analysis of primary research literature and development of presentation and writing skills. Contemporary articles are assigned on a related topic every week, and a student leads discussions with input from faculty who are experts in the topic area. The overall goal is to cover a specific topic of medical relevance (e.g., cancer, neurodegeneration) from the perspective of three primary disciplines (i.e., physiology: normal function; pathology: abnormal function; and pharmacology: intervention). 

PATH 690a: Molecular Mechanisms of Disease

This course covers aspects of the fundamental molecular and cellular mechanisms underlying various human diseases. Many of the disorders discussed represent major forms of infectious, degenerative, vascular, neoplastic, and inflammatory disease. Additionally, certain rarer diseases that illustrate good models for investigation and/or application of basic biologic principles are covered in the course. The objective is to highlight advances in experimental and molecular medicine as they relate to understanding the pathogenesis of disease and the formulation of therapies.