A one-year, ACGME-accredited clinical program under the auspices of the Departments of Pathology, Laboratory Medicine (both at Yale-New Haven Hospital and the Connecticut VA Medical Center), Genetics, and Surgery, with a second optional year in research. The mission of the fellowship includes the training of individuals to become (1) future laboratory directors and/or expert consultants in molecular diagnostics within both academic and non-academic settings and/or (2) researchers in the field of developmental diagnostics. Trainees will become thoroughly familiar with the basic biologic principles of molecular genetic pathology; principles of clinical genetics; principles of cytogenetics and the interface between molecular diagnostic assays and conventional cytogenetics; principles of biochemical genetics and testing of related disorders; technical aspects of molecular genetic testing and the interpretation of test results for cancer, hematologic disorders, inherited diseases, infectious disease, identity, drug sensitivities (pharmacogenetics), and tissue typing; and administrative, safety, ethical, and quality control issues germane to the operation of a clinical laboratory service for molecular diagnostics. Faculty include Drs. Jeffrey Sklar, Pei Hui, J. Greg Howe, Brian Smith, John McClaskey, Gary Stack, Allen Bale, Peining Li, and Laurine Bow.
Support for the second, research year will be based on a review by the faculty of the research program proposed by the fellow. Research may focus on developmental and/or applied clinical research projects, such as development of novel molecular tests; basic research relevant to disease mechanisms, with relevance to diagnosis; studies of clinicopathologic correlations; or regulatory, ethical, economic, or informatics issues related to molecular genetic pathology and molecular diagnostics. Research during this year may be conducted under the guidance of any faculty advisor within the university and in any of a wide variety of laboratories that offer an opportunity for investigation of topics pertinent to molecular genetic pathology and molecular diagnostics.
Completion of post-medical school graduate training in anatomic pathology, clinical pathology, combined anatomical and clinical pathology, or medical genetics.
Stipends commensurate with hospital policy.
Jeffrey Sklar, M.D., Ph.D.
Director of Molecular Diagnostics
Department of Pathology
Yale School of Medicine
P.O. Box 208023
New Haven, CT 06520-8023