Renal Pathology & Electron Microscopy

General Information

The Yale Renal Pathology and Electron Microscopy Laboratory is a nationally recognized center for diagnostic renal pathology and electron microscopy. It provides the most effective methodologies available for light microscopic, ultrastructural and immunological diagnosis of kidney biopsies and surgical pathology specimen. These include transmission electron microscopy, immunohistochemistry and standard and confocal immunofluorescence microscopy. There is special emphasis on the diagnosis of glomerular, tubulointerstitial and vascular kidney diseases, as well as evaluation of transplant kidney biopsies. Electron microscopy is further of value in the diagnosis of ciliary abnormalities, metabolic disorders, microbial identification, and tumor diagnosis. As one of the few clinical electron microscopy services with digital imaging capability in the nation, the Yale Renal Pathology Laboratory is well positioned to serve a wide geographic area with rapid turnaround time combined with expert consultative services.

Highlights

  • Provides high quality electron micrographs/digital images for analysis of ultrastructural pathologic changes in organ tissue.
  • Maintains the highest level of diagnostic accuracy coupled with rapid turnaround time for renal diseases, ciliary abnormalities, metabolic disorders, microbial identification, and tumor diagnosis.
  • Assists in developing new programs, such as a comprehensive program for diagnosis of immunologic diseases and the center for excellence in organ transplantation.

People

Dr. Gilbert Moeckel is Director of the renal pathology laboratory. Dr. Michael Kashgarian is the Emeritus Director of the laboratory and an active consultant on the clinical service. The laboratory is staffed by two full-time electron microscopists: Margaret Ianniello, Manager, and Judith Mitnick Ph.D. Administrative support is provided by Pamela Clark.

Facility

The laboratory is located in the Medical School, Lauder Hall LB20. Facilities include a cutting room with two Reichert Ultramicrotomes - Ultracut E and Ultracut S. An embedding area includes the Reichert Lynx Tissue Processor and the Leica EMStain automatic stainer. The Zeiss LIBRA 120 Electron Microscope is used to scan the specimens. Images are digitized from the electron microscope using the Advanced Microscopy Techniques (AMT) CCD Camera system and software.

Consult Services

Complete electron microscopy and renal biopsy consultation services are available to departments and physicians within YNHH, as well as outside hospitals and groups.

More information is available by contacting:

Renal Pathology & Electron Microscopy Laboratory
Department of Pathology
Yale University School of Medicine
P.O. Box 208023
310 Cedar Street, LH B20
New Haven, CT 06520-8023
Tel: 203.785.2750
Fax: 203.785.3348