Zenta Walther, MD, PhD

Associate Professor of Pathology; Medical Director, YNHH Tumor Profiling Laboratory

Departments & Organizations

Pathology: Experimental Pathology Graduate Program | Medical & Surgical Pathology | Molecular & Genomic Pathology

Faculty Research

Molecular Diagnostics Laboratory

Yale Combined Program in the Biological and Biomedical Sciences (BBS): Molecular Cell Biology, Genetics and Development: Molecular Mechanisms

Yale Medicine

Office of Cooperative Research


Dr. Walther is a physician-scientist with clinical expertise in gastrointestinal and liver pathology, the molecular diagnostics of surgical pathology specimens, and molecular oncology of solid tumors. Her research interests focus on epithelial cell biology, particularly the roles of membrane-associated scaffolding proteins in cell polarity and proliferation control. A new project in her lab involves characterizing the cellular functions of one such scaffolding protein, called Dlg5 (discs large 5) in the intestine. Allelic variation in the human Dlg5 gene has been linked to altered risk of Crohn's disease, a subtype of inflammatory bowel disease. However, the cellular and molecular mechanisms of Dlg5's involvement in Crohn's disease pathogenesis are unknown. The Walther lab is using tissue culture and transgenic mouse models to explore the roles of Dlg5 in enterocyte differentiation and function, maintenance of the intestinal epithelial barrier, and innate immune signalling in the intestinal mucosa.

Education & Training

MD Cornell University (1995)
PhD Rockefeller University (1994)
BS Yale University (1986)
Fellow Yale University School of Medicine
Fellow Yale University School of Medicine
Resident Yale University School of Medicine
Board Certification AB of Pathology, Anatomic Pathology (2001)

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Contact Info

Zenta Walther, MD, PhD
Patient Care Location
Surgical PathologyYale-New Haven Hospital
20 York Street, Ste EP 2-631

New Haven, CT 06510
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Office Location
Department of PathologyClinic Building
789 Howard Avenue, Ste CB 565A

New Haven, CT 06519
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Mailing Address
310 Cedar Street
PO Box 208023

New Haven, CT 06520-8023