Flora M. Vaccarino, M.D.

Grants & Patent Awards

  • Kavli Institute for Neuroscience at Yale: Micofluidics System for High Throughput Culture and Analysis of Induced Pluripotent Stem Cells (Flora Vaccarino)
  • Women’s Health Research at Yale: Gender Differences in Aging Astroglial Stem Cells (Flora Vaccarino)

Publications

  • Abyzov, A., Mariani, J., Palejev, D., Zhang, Y., Haney, M.S., Tomasini, L., Ferrandino, A., Rosenberg Belmaker, L., Szekely, A., Wilson, M., Kocabas, A., Calixto, N.E., Grigorenko, E.L., Huttner, A., Chawarsha, K., Weissman, S., Urban, A.E., Gerstein, M., and Vaccarino, F.M.: Somatic copy number mosaicism in human skin revealed by induced pluripotent stem cells. Nature (2012) 492(7429):438-42. PMCID: PMC3532053.
  • Jablonska, B., Scafidi, J., Aguirre, A., Vaccarino, F., Nguyen, V., Borok, E., Horvath, T., Rowitch, D., Gallo, V. Oligodendrocyte regeneration after neonatal hypoxia requires Fox01-   mediated p27kip1 expression. J Neurosci (2012) 32(42):14775-14793. doi: 10.1523/JNEUROSCI.2060-12.2012. NIHMSID# 416438.
  • Mariani, J., Simonini, M.V., Palejev, D., Tomasini, L., Coppola, G., Szekely, A., Horvath, T., and Vaccarino, F.M.: Modeling human cortical development in vitro using induced pluripotent stem cells. Proc. Natl. Acad. Sci. USA (2012) 109(31): 12770-12775. http://www.pnas.org/content/109/31/12770.long. PMID: 22761314. 
  • Naumova, O. Yu., Palejev, D., Vlasova, N. V., Lee, M., Rychkov, S. Yu., Babich, O. N., Vaccarino, F., and Grigorenko, E. L. (2012). Age-related changes of gene expression in the neocortex: Preliminary data on RNA-Seq of the transcriptome in three functionally distinct cortical areas. In: The Contribution of Genetic/Genomic Sciences to Developmental Psychopathology, Special Issue of Development and Psychopathology, edited by E. Grigorenko and D. Cicchetti. (2012) 24(4): 1427-1442. doi: 10.1017/S0954579412000818. PMID: 23062308.
  • Salmaso, N., Silbereis, J., Komitova, M., Mitchell, P., Chapman, K., Ment, L.R., Schwartz, M.L., Vaccarino, F.M.: Environmental enrichment increases the GFAP+ stem cell pool and reverses hypoxia-induced cognitive deficits in juvenile mice. J Neurosci (2012) 32:8930-9. Epub ahead of print. doi: 10.1523/JNEUROSCI.1398-12.2012. PMCID: PMC3399175. [Available on 2012/12/27]
  • Smith, K.M., Williamson, T.L., Schwartz, M.L., and Vaccarino, F.M.: Impaired motor coordination and disrupted cerebellar architecture in Fgfr1 and Fgfr2 double knockout mice. Brain Research (2012) 1460:12-24. Epub: 2012/05/15. PMCID: PMC3361544 [Available on 2013/6/15]
  • Stevens, H.E., Jiang, G.Y., Schwartz, M.L., and Vaccarino, F.M.: Learning and memory depend on fibroblast growth factor receptor 2 functioning in hippocampus. Biol. Psychiatry (2012) 71(12):1090-8. Epub 2012/05/01. PMCID: PMC3371339.
  • Stevens, H.E., Mariani, J., Coppola, G. and Vaccarino, F.M.: Neurobiology meets genomic science: the promise of human induced pluripotent stem cells. In: The Contribution of Genetic/Genomic Sciences to Developmental Psychopathology, Special Issue of Development and Psychopathology, edited by E. Grigorenko and D. Cicchetti. (2012) 24(4): 1443-1451. doi: 10.1017/S095457941200082X. PMID: 23062309.
  • Stevens, H.E., Su, T., Yanagawa, Y., Vaccarino, F.M. Prenatal stress delays inhibitory neuron progenitor migration in the developing neocortex. Psychoneuroendocrinology (in press). doi: http://dx.doi.org/10.1016/j.psyneuen.2012.07.011. NIHMSID# 400066.
  • Vaccarino, F.M., Kataoka, Y., Lennington, J.: Cellular and Molecular Pathology in Tourette Syndrome. In: ‘Tourette Syndrome’, edited by D. Martino and J.F. Leckman, Oxford University Press. (in press).

Presentations

  • Workshop on the Developmental Neurobiology of ASD, Simons Foundation, NY: “Growth and patterning of the neocortex and potential dysregulation in autism”.
    9/12/2012
  • Banbury Center, Cold Spring Harbor Laboratory, Cold Spring Harbor, NY: “Induced pluripotent stem cells to study autism: promise and challenges.” 9/10/12
  • Summer school on "Neural Stem Cell in Development and Disease,” Trento, Italy: “Mechanisms governing cerebral cortical expansion and morphogenesis in neural stem
    cells.” 9/06/2012
  • Kavli Workshop on “The Potential of iPS Cells in Research on Normal and Pathological Development, Disease, and Evolution,” School of Medicine, speaker and organizer.
    7/25/2012
  • 8th Hershey Conference on Developmental Brain Injury 2012, Latimer Place, UK: “Cortical neurogenesis from the astroglial lineage after perinatal hypoxic injury and
    environmental enrichment.” 6/07/2012
  • Yale-UCL Neurovascular Symposium, School of Medicine, 5/11/12: “Generation of neurons and oligodendrocytes from cortical astroglia in chronic hypoxic mice.”
  • Department of Neuroscience, Rutgers University, invited seminar: “Modeling cortical development with induced pluripotent stem cells”. 04/26/2012
  • Psychiatric iPSC workshop, NIMH, Washington, DC: “Three dimensional in vitro differentiation assays derived from iPDC”. 04/25/2012
  • Cedars-Sinai Institute of Regenerative Medicine, Los Angeles, CA: “Modeling cortial development with induced pluripotent stem cells”. 04/05/2012

Teaching Activities

  • “Stem Cells: Biology and Applications” (GENE655) Lecture on “Neural Stem cells” 11/8/2012, Yale University