Joan A. Steitz, Ph.D.

Grants & Patent Awards

• HHMI 019412 Structure and Function of Small Ribonucleoproteins in Mammalian Cells
  (3 Postdoctorals supported) 09/01/11–08/31/12, $868,701, including salaries
• NIH 2 R01-G M026154-41, Vertebrate Non-Coding RNPs: Integrating Function, Biogenesis and Survival 7/1/11–6/30/15, TDC: $170,000                                 
• 5 P01-CA16038-38, Molecular Basis of Viral and Cellular Transformation. D. DiMaio, P.I.; J.A. Steitz (Project #3): Viral Non-coding RNAs and Cell Transformation 7/1/2011–6/30/2014, TDC: $152,000  

Honors and Awards

• Yale Scholar Award endowment, named for Joan A. Steitz  (May)
• D.Sc (Hon), Rockefeller University (Jun 14)
• Pearl Meister Greengard Award (Nov 29)

Publications

• Nag, A., and Steitz, J.A. (2012). Tri-snRNP-associated proteins interact with subunits of the TRAMP and nuclear exosome complexes, linking decay to ongoing pre-mRNA splicing. RNA Biology9, 334-342. PMCID: PMC3384585
• Riley, K.J., Rabinowitz, G.S, Yario, T., Luna, J., Darnell, R., and Steitz, J.A. (2012). EBV and human microRNAs co-target oncogenic and apoptotic viral and human genes during latency. EMBO J.31, 2207–2221. PMCID: PMC3343464  
• Borah, S., Nichols, L.A., Hassman, L.M., Kedes, D.H., and Steitz, J.A. (2012). Tracking expression and subcellular localization of RNA and protein species using high-throughput single cell imaging flow cytometry. RNA.18, 1573-1579. PMCID: PMC3404377
• Steitz, J.A. (2012) Book Review: RNA: Life's Indispensable Molecule, by James E. Darnell. Science335, 39.
• Maurin, T., Cazalla, D., Yang, J-R., Bortolamiol-Becet, D., Steitz, J.A., and Lai, E.C. (2012). RNase III-independent microRNA biogenesis in mammalian cells. RNA18, 2166-2173. PMCID: PMC3504669
• Tycowski, K.T., Shu, M.-D., Borah, S., Shi, M., and Steitz, J.A. (2012). Conservation of a triple-helix-forming RNA stability element in noncoding and genomic RNAs of diverse viruses. Cell Reports2, 26-32. PMCID: PMC3430378
• Lee, N., Pimienta, G., and Steitz, J.A. (2012). AUF1/hnRNP D is a novel protein partner of the EBER1 non-coding RNA of Epstein-Barr virus. RNA18, 2073-2082. PMCID: PMC3479396
• Riley, K.J., Yario, T., and Steitz, J.A. (2012). Association of Argonaute proteins and microRNAs can occur after cell lysis. RNA18, 1581-1585. PMCID: PMC3425773
• Riley, K.J., and Steitz, J.A. (2012). The “Observer Effect” in genome-wide surveys of protein-RNA interactions. Molec. Cell, in press.
• Brown, J.A., Valenstein, M.L., Yario, T.A., Tycowski, K.T., and Steitz, J.A. (2012). Formation of triple-helical structures by the 3′-end sequences of MALAT1 and MENβ noncoding RNAs. Proc. Natl. Acad. Sci., USA109, 19202-19207. PMCID: PMC3511071
• Herbert, K.M., Pimienta, G., DeGregorio, S.J., Alexandrov, A., and Steitz, J.A. (2012). DGCR8 phosphorylation increases protein stability and cell proliferation. Submitted.
• Alexandrov, A., Colognori, D., Shu, M-D., and Steitz, J.A. (2012). Human spliceosomal protein CWC22 plays a role in coupling splicing to exon junction complex deposition and nonsense-mediated decay. Proc. Natl. Acad. Sci., USA. published ahead of print December 10, 2012, doi:10.1073/pnas.1219725110.
• Steitz, J.A. (2012). Ribosome Profiling:  1960s’ Style. Submitted for 50th Anniversary of MRC Laboratory of Molecular Biology (LMB).

Presentations

Invited Lectures at Meetings

• Project Prometheus Chair Introduction, Shantou University Guangdong, P.R., China
• Keystone Symposium on Protein-RNA Interactions in Biology and Disease, Santa Fe, NM
• Symposium in Honor of Witek Filipowicz, Friedrich Miescher Institute for Biomedical Research, Basel, Switzerland NICHD Scientific Retreat Speaker, NIH, Bethesda, MD
• 27th Annual National MD/PhD Student Conference, Keynote Speaker II, Keystone, CO
• Gordon Research Conference, Salve Regina University, Newport, RI
• EMBO/EMBL The Complex Life of mRNA Symposium (Co-chair), Heidelberg, Germany
• Jane Coffin Childs Memorial Fund 75th Anniversary Symposium, Challenges in Biomedical Sciences, Yale University, New Haven, CT
• Genetics Society Autumn Meeting, At the Cutting Edge of Molecular Biology: 25 Years of Genes & Development, London

Research Seminars

• Ruth and Eddie Hughes Lecture, California Institute of Technology, Pasadena, CA
• The Alvine Engineering Professional Effectiveness and Enrichment Program, University of New Haven, New Haven, CT
• Math and Science (MAS) Familias Dinner, Yale University, New Haven, CT
• Luminaries of Science Lecture, New York University Abu Dhabi; and Class Lecture, New York, NY
• 37th Annual Ritter Lecture, Miami University, Oxford, OH  
• Bulldog Days Master Class, Yale University, New Haven, CT
• Microbiology Graduate Program Seminar Series, Yale University, New Haven, CT
• Carter-Wallace Lectures, Princeton University, Princeton, NJ
• Weinhouse Lecturer, Thomas Jefferson University, Philadelphia, PA
• Senior Scientist Lecture Series, Yale University College London (UCL) Collaborative, UCL, London, UK
• Family Weekend Professor Lunch, Yale University, New Haven, CT
• Distinguished Role Model in Life Sciences, Northwestern University Evanston, IL
• Joyce L. Hamlin Distinguished Lecture, University of Virginia, Charlottesville, VA
• Laureate Lecture Series, University of Pittsburgh School of Medicine, Pittsburgh, PA

Women in Science Seminars

• Women in Science Seminar, California Institute of Technology, Pasadena, CA (Jan 20)
  Project Prometheus Breaking the Barriers Lecture, Shantou University Guangdong, P.R., China
• Beyond Bias and Barriers:  Prospects for Women in Science, Miami University, Oxford, OH
• American Society for Microbiology Special Interest Session on the Status of Women in Microbiology, San Francisco, CA
• Undergraduate Women in Science at Yale (WISAY) Dinner, Yale University, New Haven, CT
• Research Centers in Minority Institutions International Symposium on Health Disparities, Keynote Lecturer, San Juan, PR

Teaching Activities

• Spring 2012: MBB 301b (in charge) 12 1.5-hr. lectures (= 1/2 of course)
• Fall 2012: MBB 449a (in charge)  4 1.5-hr. lectures + 4 discussion sessions (= 1/3 of course)

Yale and Outside Committee Work

Department:   

Spring:

• Co-Vice Chair
• Educational Oversight Committee (Co-Chair)
• Executive Committee
• Qualifying Exam Committee (Chair)
• Space Committee (Chair)
• Undergraduate Advisor, Class of ’14

Fall: 

• Co-Vice Chair
• DUS
• Educational Oversight Committee (Co-Chair)
• Organized (and funded) publication of Annals of the C Wing Seminar, 2012
• Qualifying Exam Committee (Chair)
• Stockroom Committee
• Undergraduate Advisor, Class of ’14

Research Committees

• Nicole Darricarrere (Cell Biology)                             
• Matthew Eckwahl (Cell Biology)
• Eric Guo (Cell Biology)
• Xiao Huang (Cell Biology)
• Orn Itsathitphaisarn                                               
• Minsun Jeong (Cell Biology)
• Stephen Mastriano (Genetics)                                    
• Ifeoma Nwigwe         
• Bob Ross (Cell Biology)
• Katherine Uyhazi (Cell Biology)
• Valeria Yartseva
• Vincent Yip

Qualifying Exams

• Vincent Yip               

Other Yale

• Scholar Awards Committee
• Silliman Lecture Committee (Chair)
• Dean’s Advisory Planning Committee
• Steering Committee, Women Faculty Forum; Co-Chair, Committee on Institutional Change

Non-Yale Service

• Canvassing Panel, Section 21, National Academy of Sciences (teleconference, January)
• Albany Medical Center Prize in Medicine and Biomedical Research, National Selection Committee, New York, NY
• Committee on Scientific Affairs, Rockefeller University, New York, NY  
• Rita Allen Foundation Jury, Rockefeller U, New York, NY
• NAS Award in Molecular Biology Presentation, NAS, Washington, DC
• Jane Coffin Childs Fund for Medical Research, Joint Dinner and Board of Managers Meeting, New Haven, CT
• NICHD Board of Scientific Counselors, Bethesda, MD
• Evaluation of HHMI Applications for International Investigators
• HHMI Scientific Meeting, Nucleic Acids and Interacting Proteins, Auburn, VA
• ERC Synergy Grant Evaluation, Step 2a Panel Meetings, Brussels, Belgium
• Coalition for Life Sciences Board Meeting, HHMI, Chevy Chase, MD
• National Institute of General Medical Sciences, Search Committee for Director, Position Interviews, Bethesda, MD
• Wiley Prize Jury, Rockefeller University, New York, NY

Editorial Work

• Editorial Board, Genes and Development
• Associate Editor, RNA
• Member Editor, Proceedings of the National Academy of Sciences
• Associate Editor, Journal of Cell Biology