Jackie A. Fretz, PhD

Assistant Professor of Orthopaedics and Rehabilitation

Departments & Organizations

Orthopaedics & Rehabilitation

Faculty Research

Biography

I obtained my BS in Biochemistry and Molecular Biology from the University of New Hampshire, and PhD in Biochemistry from the University of Wisconsin--Madison. My research career has always focused on transcriptional regulation of cell fate. This has included NFATc1 in osteoclasts, the Vitamin D Receptor in osteoblasts, and EBF1 in mesenchymal progenitors. Currently I am researching the actions of EBF1 in kidney development, renal disease, and the associated chronic kidney disease-mineral bone disorder that develops.

Education & Training

PhD University of Wisconsin-Madison (2007)
BS University of New Hampshire, Biochemistry and Molecular Biology (2002)
Research Scientist Yale School of Medicine
Postdoctoral Fellowship Yale School of Medicine

Honors & Recognition

  • John Haddad Young Investigator AwardAmerican Society for Bone and Mineral Research (2010)

  • Young Investigator AwardAmerican Society for Bone and Mineral Research (2009)

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Contact Info

Jackie A. Fretz, PhD
Lab Location
Tompkins Memorial Pavilion
789 Howard Avenue, Ste 522/515

New Haven, CT 06519
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Office Location
Tompkins Memorial Pavilion
789 Howard Avenue, Ste 522A

New Haven, CT 06519
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Mailing Address
PO Pox 708071
MORTHO

New Haven, Connecticut 06520-8071

Curriculum Vitae

Trichrome staining of 3 month old Ebf1-/- mouse kidney

Ebf1 deletion results in hypoplastic kidneys with a thinned cortex and immature peripheral glomeruli. By 3 months surviving mice exhibit interstitial fibrosis, glomerulosclerosis, tubular dilation, and hematuria.