Jonathan Newman Grauer, MD

Professor of Orthopaedics and Rehabilitation and Professor of Pediatrics; Co-Director, Orthopaedic Spine Service; Co-Director, Yale New Haven Hospital Spine Center; Vice Chair of Clinical Research and Director of Clinical Information Systems

Research Interests

Anatomy; Spine; Health Care

Research Organizations

Orthopaedics & Rehabilitation

Faculty Research

Research Summary

Dr. Grauer's laboratory performs multiple studies critically evaluating aspects of orthopedic and spine clinical practice.

  • Current clinical research studies
    • Multiple national database outcome studies
    • Multiple cohort studies
  • Current basic / translational science studies
    • None
  • Current clinical trials
    • Pfizer, “Phase 2B, randomized, double-blind, placebo-controlled, study to evaluate the safety and efficacy of staphylococcus aureus 4-antigen (SA4AG) vaccine in adults undergoing elective posterior instrumented lumbar spinal fusion procedures”, co-investigator.
    • Spinal Kinetics, “Concurrently controlled, multi-center study to evaluate the safety and effectiveness of the Spinal Kinetics™ M6-C artificial cervical disc compared to anterior cervical discectomy and fusion (ACDF) for the treatment of symptomatic cervical radiculopathy”, co-investigator.
    • Orthofix, “Safety and efficacy of pulsed electromagnetic fields (Cervical-Stim®) as an adjunct to enhance union in conservatively treated Type II fractures of the odontoid process”, co-investigator
  • Current grants
    • Multiple Yale University School of Medicine Medical Student research supports awards


Extensive Research Description

Dr. Grauer directs an active research group that focuses on clinical outcomes of spine and orthopaedic patients. In an era of striving to optimize patient outcomes, it is crucial that we learn from our patients to advance clinical care.

National databases track large numbers of patients and allow for the study of such outcomes. Dr. Grauer works closely with his student and resident team to draw clinically meaningful messages from large data sets. What patients will do best from an intervention? Which technique is best for which person? Who is at risk for an adverse event? These are just some of the questions being addressed.

As with any type of research, studies based on national databases have both advantages and limitations. Balancing the use of such databases, Dr. Grauer’s team works to delineate the limitation of national database work and strives to optimize studies based on their data. In doing so, they work to draw the most meaningful and valid conclusions possible.

In addition to the above-noted studies, Dr. Grauer’s team is active with studies looking at patients treated locally. With studies evaluating diagnostic imaging modalities, patient characteristics, and patient outcomes, they are able to study more detailed local data.

Overall, Dr. Grauer mentors many Yale medical students and fellows in performing research studies. The team has received multiple awards. He and his group have given over 250 research talks at national and international meetings, and co-authored over 150 peer-reviewed scientific papers.

Selected Publications

Full List of PubMed Publications

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Contact Info

Jonathan Newman Grauer, MD
Patient Care Location
Yale Spine Service1 Long Wharf Drive, Ste 6th floor
New Haven, CT 06511
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Office Location
Administrative Office47 College Street
New Haven, CT 06510
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Mailing Address
P.O. Box 208071
New haven, CT 06520-8071