Winifred Mak MD, PhD

Assistant Professor of Obstetrics, Gynecology, and Reproductive Sciences; Director, Early Recurrent Pregnancy Loss Program

Research Interests

Embryogenesis; Epigenetic regulation of placental development; Role of Pumilio; RNA binding protein in oogenesis and embryogenesis; Trophoblast stem cells

Research Summary

Dr Mak, is currently one of a few physician-scientists appointed by the NIH as a WRHR (Women's Reproductive Health Research) scholar. She is presently carrying out her postdoctoral research under the supervision of Dr Haifan Lin, the director of the Yale Stem Cell Center. Her current projects include investigating the role of an RNA binding protein, Pumilio in the ovary and during embryonic development using a transgenic knockout model; the epigenetic regulation of trophoblast stem cells and their future potential use in placental therapy.

Selected Publications

  • Nangia A.K., Luke B., Smith JF., Mak W., Stern J.E.; the SART Writing Group (2011). National study of factors influencing assisted reproductive technology outcomes with male factor infertility. Fertil Steril. Sep;96(3):609-14.
  • Senner C. E., Nesterova T.B., Norton S., Dewchand H., Godwin J., Mak W., Brockdorff N. (2011). Disruption of a conserved region of Xist exon 1 impairs Xist RNA localisation and X-linked gene silencing during random and imprinted X chromosome inactivation. Development. (2011) 138(8):1541-50.
  • Mak, W and Dokras, A. (2009) Polycystic Ovarian Syndrome and the risk of cardiovascular disease and thrombosis. Semin. Thromb. Hemost. 35(7): 613-20.
  • Maltepe,E., Krampitz,G.W., Okazaki,K.M., Red-Horse,K., Mak,W., Simon,M.C., Fisher,S.J. (2005). Hypoxia-inducible factor-dependent histone deacetylase activity determines stem cell fate in the placenta. Development. 132(15):3393-403.
  • Mak,W., Nesterova,T. B., de Napoles, M., Appanah, R.., Yamanaka, S., Otte, A. P., Brockdorff, N. (2004). Reactivation of the paternal X chromosome in early mouse embryos. Science 303 (5658): 666-669.
  • Mak, W., Baxter, J., Silva, J., Newall, A. E., Otte, A. P. and Brockdorff., N. (2002). Mitotically stable association of Polycomb group proteins Eed and Enx1 with the inactive X chromosome in trophoblast stem cells. Curr. Biol. 12(12):1016-1020.
  • Johnson, N. P., Mak, W. and Sowter M. C. (2002). Laparoscopic salpingectomy for women with hydrosalpinges enhances the success of IVF: a Cochrane review. Hum Reprod. 17(3):543-548.

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