Seth M Guller PhD
Senior Research Scientist in Obstetrics, Gynecology, and Reproductive Sciences; Director, Gyn/Endocrine Laboratory
Research Interests
Placental physiology; intrauterine growth restriction; preeclampsia; adverse pregnancy outcomes
Research Summary
Dysfunction of the human placenta has been linked with several complications of pregnancy including preeclampsia, intrauterine growth restriction, and cerebral palsy. Our research group uses cell biology and molecular techniques to identify potential causes of these pregnancy outcomes which are associated with significant newborn and maternal mortality and morbidity.
Selected Publications
- Guller S, Buhimschi CS, Ma YY, Huang S TJ, Yang L, Kuczynski E, Zambrano E, Lockwood CJ, 8. Buhimschi IA (2008) Placental expression of ceruloplasmin in pregnancies complicated by severe preeclampsia. Laboratory Investigation 88:1057-1067. PMCID: PMC2682720
- Guller S (2009) Role of the syncytium in placenta-mediated complications of preeclampsia. Thromb Res 124:389-392. PMCID: PMC2764997
- Guller S Tang Z, Ma YY, Di Santo S, Sager R, Schneider,H (2010) Protein composition of microparticles shed from human placenta: potential role in angiogenesis and fibrnolysis in preeclampsia. Placenta, in press, PMCID:PMC Journal—In Process.
- Toti P, Arcuri F, Tang Z, Schatz F, Zambrano E, Mor G, Niven-Fairchild T, Abrahams VM, Krikun G, Lockwood CJ, Guller S (2010) Focally increased levels of fetal macrophages in pregnancies with histological chorioamnionitis (HCA): potential role of fibroblast monocyte chemotactic protein-1(MCP-1). Am J Reprod Immunol, PMCID:PMC Journal—In Process.
