Michael J. Paidas MD

Professor of Obstetrics, Gynecology, and Reproductive Sciences; Vice Chair, Obstetrics; Program Director, Maternal Fetal Medicine Fellowship; Director of the Yale Women and Children's Center for Blood Disorders and Preeclampsia Advancement; Co-Director, National Hemophilia Foundation - Baxter Clinical Fellowship Program at Yale; Division of Maternal Fetal Medicine

Biographical Info

Michael J. Paidas, M.D. is Professor of Obstetrics, Gynecology, and Reproductive Sciences, Yale University School of Medicine; Vice Chair, Obstetrics; Program Director, Maternal Fetal Medicine Fellowship; Director of the Yale Women and Children’s Center for Blood Disorders and Preeclampsia Advancement, and Co-Director of the National Hemophilia Foundation-Baxter Clinical Fellowship Program at Yale; Divison of Maternal Fetal Medicine.

Dr. Paidas is the recipient of The David J. Leffell, M.D. Prize for Clinical Excellence at Yale in 2010, given to one member of the Yale Medical Group annually. In 2012, Dr. Paidas received the Dean’s Award from the Tufts Medical Alumni Association. Dr. Paidas is included in the top 1% physician by specialty in the nation according to US News and World Report. He has been recognized by the March of Dimes and is included in Best Doctors in America. Dr. Paidas has also received the National Faculty Award by the Counsel on Resident Education in Obstetrics and Gynecology.

Dr. Paidas received his medical degree from Tufts University School of Medicine in 1987 and completed his internship and residency in Obstetrics and Gynecology in 1991 at Pennsylvania Hospital. In 1993, Dr. Paidas completed a Fellowship in Maternal Fetal Medicine at the Mount Sinai School of Medicine in New York. In 2013, Dr. Paidas was awarded a Master of Arts, Honorary Degree, from Yale University.

Dr. Paidas's career in medicine has focused on women’s health with special emphasis on blood disorders, reproduction, pregnancy complications and the latter’s impact on health and disease. His activities span direct patient care, translational research and clinical trials. Dr. Paidas’s research has been supported by federal and non- federal funding agencies. His notable contributions include: description of the regulatory factors of the Protein C system; clinical use of recombinant antithrombin in disease states; elucidation of the subsequent cardiovascular and non-cardiovascular health consequences of hypertensive disorders and preterm delivery in the largest population based studies published to date.

Dr. Paidas and collaborators have described the genomic and proteomic effects of Preimplantation Factor (PIF), a novel mammalian embryo derived factor which regulates maternal receptivity to pregnancy and possesses key immune modulatory properties. Subsequent animal studies using a synthetic analogue of native PIF have shown benefit in animal models related to a variety of immune diseases, including multiple sclerosis and graft versus host disease.

Dr. Paidas is the lead Prinicipal Investigator of a multicenter preeclampsia treatment clinical trial, entitled Prospective Randomized Double-Blind, Placebo Controlled Evaluation of the Pharmacokinetics, Safety and Efficacy of Recombinant Antithrombin Versus Placebo in Preterm Preeclampsia (PRESERVE-1).

Dr. Paidas has expertise in prenatal ultrasound, invasive fetal diagnostic and therapeutic procedures. His academic profile includes over 500 published manuscripts, abstracts, books, chapters, presentations or courses.

International Activity

  • “Preimplantation factor (PIF): a biomarker for viable embryo selection after in vitro fertilization and for pregnancy outcome.”
    United States; France; Greece(2012)
    This proposal is a multicenter study which investigates the potential role of Preimplantation Factor as a diagnostic test in two settings; namely, to predict IVF success when measured in embryo culture media, and to predict viable pregnancy and a range of placenta mediated complications.
  • Textbook: Hemostasis and Thrombosis in Obstetrics and Gynecology
    United Kingdom(2011)
    Blackwell Publishing, first edition, 2011. Editors: Paidas Michael J., Hossain Nazli, Shamsi Tahir, Rodger M, Langhoff-Roos Jens, Lockwood Charles J. Wiley Blackwell, Oxford, OX4 2DQ, UK
  • “NOICH study”: This study is an international study to determine the breath and experience of antenatal treatment of alloimmune thrombocytopenia.
    Leiden, Netherlands(2008)
    Research collaboration to determine the optimal management of alloimmune thrombocytopenia during pregnancy
  • Biomarkers for the detection of pregnancy complications, role of anticoagulation in the prevention of placenta mediated complications, use of recombinant factor VIIa to treat postpartum hemorrhage
    Karachi, Pakistan(2006)
    Research collaboration to investigate causes, prevention strategies and treatment regimens for pregnancy complications, especially preeclampsia and postpartum hemorrhage in a developing country
  • Adverse Pregnancy Outcome, Subsequent Cardiovascular
    Copenhagen, Denmark(2004)
    Research collaboration to investigate risk factors for pregnancy complications and subsequent maternal health consequences
  • Multigate Doppler with Global Acquisition and Signal Processing (G.A.S.P.) in the uteroplacental, fetal circulations and gynecologic ultrasound.
    Florence, Italy; Milan, Italy(2001)
    Research collaboration to develop and implement an improved, non-invasive Doppler ultrasound technique

Education & Training

Fairfield University (1982)
Tufts University School of Medicine (1987)
Yale University (2013)
Pennsylvania Hospital, Obstetrics & Gynecology
Mount Sinai Medical Center, Maternal-Fetal Medicine

Honors & Recognition

  • The National Institutes of Health and the Canadian Institutes of Health Research, 5th Annual Summer Institute in Maternal- Fetal Pharmacology, La Sapiniere, Val-David, Quebec, graduate
    NICHD and CIHR (2009)
  • National Faculty Award, CREOG
    CREOG (2009)
  • Flagship Referral Network Member
  • Teaching Award
    Tufts University School of Medicine (1995)
  • Headmaster’s Scholarship, Fairfield University
    Fairfield University (1978-82)
  • Distinguished Alumni at 25th Class Reunion, Tufts University School of Medicine (speaker)
    Tufts University School of Medicine (2012)
  • Best Doctors, New York Magazine
    New York Magazine (2007)
  • Member
    American Society of Hematology (2004)
  • The New York Obstetrical Society, Fellow
    The New York Obstetrical Society (2000)
  • Globus Award, Prize Paper for 1994
    The Mount Sinai Journal of Medicine (1995)
  • Alpha Epsilon Delta, Treasurer
    Alpha Epsilon Delta, Fairfield University (1982)
  • Co-Director National Hemophila Foundation - Baxter Clinical Fellowship at Yale
    National Hemophilia Foundation (2009)
  • Bellevue Obstetrical and Gynecological Society, Member
    Bellevue Obstetrical and Gynecological Society, New York University (1998)
  • Frontiers in Reproduction: Molecular and Cellular Concepts and Applications. Marine Biological Laboratory, Woods Hole graduate
    NICHD (1998)
  • Thomas R. Boggs Award - Outstanding Obstetrical Resident in Intensive Care Nursery
    Pennsylvania Hospital (1988)
  • Best Doctors in America
    Best Doctors in America (2005)
  • 4th Annual NICHD Aspen Conference, participant
    NICHD (1992)
  • S. Leon Israel Prize Paper Award
    Philadelphia Obstetrical Society (1991)
  • The David J. Leffell, M.D. Prize for Clinical Excellence at Yale
    Yale School of Medicine (2010)
  • US News and World Report, Top 1% Physician In Nation (by specialty)
    US News and World Report (2012)
  • Tufts Medical Alumni Association, Dean's Award, Recipient
    Tufts University School of Medicine (2012)
  • America's Top Doctor, Castle Connolly, 11th Edition
    Castle Connolly (2012)
  • Board of Permanent Officers, Yale University School of Medicine
    Yale University School of Medicine (2012)
  • US News and World Report, Top 1% Physicians In Nation
    US News and World Report (2012)
  • Distinguished Alumni at 25th Class Reunion, Tufts University School of Medicine (speaker)
    Tufts University School of Medicine (2012)
  • New York Magazine, Best Doctors, Castle Connolly
    New York Magazine (2012)
  • National Hemophilia Foundation
    Medical Advisory Board Member (2009)
  • Hemostasis and Thrombosis Research Society
    Research Subcommittee Member (past - Board of Director) (2008)

Professional Service

  • SMFM Monograph State of High Risk Pregnancy, invited thought leader, medical complications of pregnancy, Society for Maternal Fetal Medicine (2009 - current)
  • Member of registry, National Institutes of Health (2008 - current)
  • Member, International Stillbirth Alliance (2007 - current)
  • Member, American College of Obstetricians and Gynecologists (2007 - current)
  • Member, Society for Gynecologic Investigation (2006 - current)
  • Invited Reviewer, Canadian Institutes of Health Research (2005 - current)
  • Member, Centers for Disease Control (2003 - present)
  • Member, National Heart, Lung, and Blood Institute Special Emphasis Panel (01/01/2013)
  • Member, Society for Maternal Fetal Medicine and American College of Obstetrician Gynecologists (01/01/2013)
  • Presenter, NIH/NIHLBI (01/01/2012)
  • Participant, NHLBI Workshop (01/01/2010)
  • Member, Center for Disease Control (01/01/2003 - 06/03/2013)
  • Member, New Haven Obstetrical Society (01/01/2002 - 01/01/2014)
  • Member, American Institute of Ultrasound in Medicine (01/01/1996 - 01/01/2014)
  • Member, Society for Maternal Fetal Medicine (01/01/1991 - 01/01/2014)
  • Member, American College of Obstetricians and Gynecologists, (01/01/1988 - 01/01/2014)

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