Yale researchers investigate effects of Heparin in pregnant women

Investigators at Yale discovered that Heparin (a potent anti-coagulation drug) elevates Circulating Soluble fms-Like Tyrosine Kinase-1 (sFlt-1) immunoreactivity in pregnant women. sFlt-1 was previously proposed as responsible for preeclampsia, a medical condition characterized by high maternal morbidity and mortality. However, this study demonstrates that upregulation of circulating sFlt-1 immunoreactivity in pregnancy is not always associated with adverse outcomes, and that heparin's protective effects, if any, cannot be explained by promotion of angiogenesis. This study was recently published in Circulation – November 2011. Details about this research can be found here.