Infertility Research

Infertility represents a significant problem for women today. Through countless hours of research many discoveries have been made towards addressing the underlying causes.

There are many ways to research infertility. One important aspect is to focus on Markers of Endometrial Receptivity. I have been involved with many projects regarding this area. See the list of articles I have co-authored below:

  1. Kliman HJ, Feinberg RF, Schwartz LB, Feinman MA, Lavi E, Meaddough EL. (1995) A human endometrial mucin identified by MAG (mouse ascites Golgi) antibodies: menstrual cycle-dependent localization suggests a link to early implantation events. Am J Pathology 146:166-181.
  2. Acosta AA, Elberger L, Borghi M, Calamera JC, Chemes H, Doncel GF, Kliman H, Lema B, Lustig L, Papier S. (2000) Endometrial dating and determination of the window of implantation in healthy fertile women. Fertility and Sterility, 73:788-798.
  3. Kliman HJ, Keefe DL. (2002) Implantation: The challenge of assessment and treatment. Family Building, 1:12-23.
  4. Dubowy RL, Feinberg RF, Keefe DL, Doncel GF, Williams SC, McSweet JC, Kliman HJ. (2003) Improved endometrial assessment using cyclin E and p27. Fertil Steril, 80:146-56.
  5. Catalanotti JS, Spandorfer SD, Barmat LI, Rosenwaks Z, McSweet JC, Kliman HJ. (2006) Mouse Ascites Golgi (MAG) Mucin Expression Abnormalities in Natural Cycle Endometrial Biopsies Predict Subsequent In Vitro Fertilization-Embryo Transfer (IVF-ET) Failure. Fertil Steril, 85:255-258.
  6. Kliman HJ, Honig S, Walls D, Luna M, McSweet JC, Copperman AB. Optimization of endometrial preparation results in a normal endometrial function test® (EFT®) and good reproductive outcome in donor ovum recipients. J Ass Reprod Genet, online Sept. 19, 2006.
  7. Rackow BW, Kliman HJ, Taylor HS. GnRH antagonists may affect endometrial receptivity. (2008) Fertility & Sterility, 89:1234-9.

Markers of Endometrial Receptivity represents a significant area of research on infertility. I have been involved with many projects regarding this area. The list of the abstracts below are all ones I have co-authored.

  1. Kliman HJ, Feinberg RF, Feinman MA, Liu M, Buchanan E. Mouse ascites golgi (MAG) factor: a potential menstrual cycle dependent marker of endometrial receptivity to human implantation. 39th Annual Meeting of the Society for Gynecologic Investigation, 1992.
  2. Kliman HJ, Feinberg RF, Meaddough EL, Schwartz LB. (1992) Mouse ascites golgi (MAG) factor: A mucin which may be a potential menstrual cycle dependent marker of endometrial receptivity to human implantation. Placenta 13:A35.
  3. Schwartz LB, Meaddough EL, Lyttle CR, Penzias AS, Naftolin F, Kliman HJ. (1992) Rat mouse ascites golgi (MAG) factor: A potential animal model for studying endometrial receptivity to implantation.Placenta 13:A57.
  4. Kliman HJ, Schwartz LB, Naftolin F, Lyttle CR, Meaddough EL. MAG (mouse ascites Golgi) mucin: menstrual cycle variation, progesterone regulation, and role in endometrial receptivity. Second International Endometrium Conference, Bologna, Italy, 1993.
  5. Kliman HJ, Meaddough EL, Keefe DL. MAG-mucin staining of endometrial glands in day 16 biopsies during mock cycles predicts pregnancy outcomes in donor egg program patients. 42nd Annual Meeting of the Society for Gynecologic Investigation, 1995.
  6. Kliman HJ, Meaddough EL, Keefe DL. MAG-mucin expression in day 16 endometrial biopsies during mock cycles predicts pregnancy outcomes in donor egg program patients. IXth International Congress on IVF, Vienna, Austria, April, 1995.
  7. Kliman HJ, Keefe DL. Route of progesterone affects rates of endometrial gland dyssynchrony in donor-egg patients undergoing mock cycles. IXth International Congress on IVF, Vienna, Austria, April, 1995.
  8. Kliman HJ, Keefe DL. MAG mucin expression predicts pregnancy outcome in donor egg patients and when absent may identify those patients who can benefit from high dose luteal phase progesterone.American Society for Reproductive Medicine, Seattle, WA, October, 1995.
  9. Kliman HJ, Feinberg RF, Grifo JA, Keefe DL. Patients with Unexplained Infertility Exhibit Correctable Defects in MAG Mucin Expression. American Society for Reproductive Medicine, Boston, 1996.
  10. HJ Kliman, P VanDeerlin, RF Feinberg. Estrogen Treatment Converts MAG-Negative (Unreceptive) Endometrium to MAG-Positive (Receptive).
  11. HJ Kliman, LI Barmat, and FF Wang. MAG Mucin Expression Abnormalities in Natural Cycle Biopsies Predict Subsequent IVF Failure.
  12. HJ Kliman, RF Feinberg, P VanDeerlin, LI Barmat, M Moomjy, JA Grifo, DL Keefe, FF Wang, DL Olive. Glandular Developmental Arrest (GDA): A Unifying Model of Reproductive Endometrial Pathology. ASRM Prize winning poster, 1997 National Meeting, Cincinatti, Ohio
  13. HJ Kliman, JS Arruda, RF Feinberg, DL Keefe. Absence of biochemical or morphologic markers of endometrial glandular development in a mock cycle predicts pregnancy failure in a subsequent donor oocyte transfer cycle. American Society for Reproductive Medicine, San Francisco, 1998.
  14. Kliman HJ, P VanDeerlin, BA Lessey, RF Feinberg. ß3 integrin and MAG mucin in luteal phase glandular endometrium: a comparative marker study. American Society for Reproductive Medicine, Toronto, Canada, 1999.
  15. Kliman HJ, L Elberger, AA Acosta, GF Doncel, HS Taylor, EA Nannenberg, KM Mitchell. Proven fertile control patients have a low incidence of histologic or MAG mucin expression abnormalities.American Society for Reproductive Medicine, Toronto, Canada, 1999.
  16. RL Dubowy, HS Taylor, EA Nannenberg, H Zhang, HJ Kliman. Cyclin E and p27 are potential markers of endometrial receptivity. 2000 Annual Meeting of the Society for Gynecologic Investigation, Chicago, IL, 2000.
  17. RL Dubowy, RF Feinberg, HJ Kliman. Endometrial biopsy and infertility evaluation: new insights from cyclins. American Society for Reproductive Medicine, San Diego, CA, 2000.
  18. Kliman HJ, Spandorfer SD, Barmat LI, Rosenwaks Z, Catalanotti JS, McSweet JC. MAG mucin expression abnormalities in natural cycle biopsies predict subsequent IVF failure. 2001 Annual Meeting of the Society for Gynecologic Investigation, Toronto, ON.
  19. Kliman HJ, McSweet JC, Grunert GM, Cardone VRS. Efficacy of the Endometrial Function Test (EFT) in Assisted Reproductive Technology (ART) Practice. 2002 Annual Meeting of the American College of Obstetricians and Gynecologists, Los Angeles, CA.
  20. Kliman HJ, McSweet JC, Grunert GM, Cardone VRS, Cadesky K, Keefe DL. The Endometrial Function Test (EFT) Directs Care and Predicts Art Outcome. American Society for Reproductive Medicine, Seattle, Washington, 2002.
  21. Kliman HJ, Adel T, Isaac BR, Khosla N, McSweet JC, Franco A, Taylor HS, Santoro NF. Menstrual, Hormonal and Endometrial Evaluation of a Woman Traversing the Menopause: Frequent and Silent Anovulation and Endometrial Dysfunction. 2003 Annual Meeting of the Society for Gynecologic Investigation, Washington, DC.
  22. Sarno JL, Kliman HJ, Taylor HS. PBX2 and MEIS 1 are HOXA10 co-activators in human endometrium. 2004 Annual Meeting of the Society for Gynecologic Investigation, Houston, TX.
  23. Lorch AC, Franco A, McSweet JC, Keefe DL, Kliman HJ. Telomerase expression in fertile patients compared to infertile patients with thin endometria. Oral presentation at the 60th Annual Meeting of the American Society for Reproductive Medicine (ASRM), October 16-20, 2004, Philadelphia, PA.
  24. Stephenson M, Houlihan E, Karrison T, Franco A, McSweet JC, Kliman HJ. Successful treatment of endometrial-associated recurrent pregnancy loss (RPL): A blinded, controlled study. Oral presentation at the 60th Annual Meeting of the American Society for Reproductive Medicine (ASRM), October 16-20, 2004, Philadelphia, PA.
  25. Willman SP, Kliman HJ. Comparison of the Luteal Phase after Pituitary Suppression with GnRH-agonist versus GnRH antagonist in Controlled Ovarian Hyperstimulation. 61st Annual Meeting of theAmerican Society for Reproductive Medicine (ASRM), October 15-19, 2005, Montreal, Canada
  26. Kliman HJ, Copperman AB, Honig S, Walls D, McSweet JC. Optimization of endometrial preparation results in a normal Endometrial Function Test® (EFT®) and good reproductive outcome in donor ovum recipients. 61st Annual Meeting of the American Society for Reproductive Medicine (ASRM), October 15-19, 2005, Montreal, Canada
  27. Rackow BW, Kliman HJ, Taylor HS. GnRH antagonists do not affect peri-implantation endometrial HOXA10 expression. 61st Annual Meeting of the American Society for Reproductive Medicine (ASRM), October 15-19, 2005, Montreal, Canada

See the list of patents related to technology and medication related to Infertility below, and click on the links to learn more about them.