Dr. Silasi's Lab

Research Interests

1. Role of IP-10 in the mechanism of preterm labor after viral infection: IP-10 (also known as Interferon gamma-induced protein of 10kDa) is a chemoattractant for activated T-cells. It is secreted by monocytes, endothelial cells, and fibroblast cells. It is induced by interferon, and is clinically useful as a prognostic indicator for patients with Hepatitis C and HIV. In pregnancy, elevated amniotic fluid levels of IP-10 at midtrimester have been associated with preterm delivery before 32 weeks, while increased expression of IP-10 has been shown in placentas with histological chronic chorioamnionitis. A two-hit model of preterm labor and delivery has previously been developed in the lab, and IP-10 levels are seen to increase in correlation with the model.

2. Interaction between cell types at the maternal-fetal interface: The maternal-fetal interface is comprised of maternal decidua and immune cells interfaced with fetal trophoblast, immune, and endothelial cells. While much research has focused on the behavior of individual cells such as the trophoblast or maternal immune cells, little is known about how these cells interact with each other in order to maintain pregnancy success or during complications of pregnancy.

Lab Members


Bio Profile

Michelle Silasi, MD

Principal Investigator

Assistant Professor of Obstetrics, Gynecology, and Reproductive Sciences

Publications

Silasi M, Cardenas I, Kwon JY, Racicot K, Aldo P, Mor G: Viral infections during pregnancy. Am J Reprod Immunol. 2015 Mar; 2015 Jan 13. PMID: 25582523

Racicot KE, Wünsche V, Auerbach B, Aldo P, Silasi M, Mor G: Human chorionic gonadotropin enhances trophoblast-epithelial interaction in an in vitro model of human implantation. Reprod Sci. 2014 Oct; 2014 Feb 11. PMID: 24520082

Racicot K, Kwon JY, Aldo P, Silasi M, Mor G: Understanding the complexity of the immune system during pregnancy. Am J Reprod Immunol. 2014 Aug; 2014 Jul 4. PMID: 24995526

Silasi DA, Gallo T, Silasi M, Menderes G, Azodi M: Robotic versus abdominal hysterectomy for very large uteri. JSLS. 2013 Jul-Sep. PMID: 24018076

Silasi M: Viral invasion of the amniotic cavity (VIAC) in the midtrimester of pregnancy. Am J Reprod Immunol. 2013 Mar. PMID: 23384234

Silasi M, Mor G: Decidual stromal cells as regulators of T-cell access to the maternal-fetal interface. Am J Reprod Immunol. 2012 Oct; 2012 Aug 31. PMID: 22935072

Bixel K, Silasi M, Zelop CM, Lim KH, Zsengeller Z, Stillman IE, Rana S: Placental origins of angiogenic dysfunction in mirror syndrome. Hypertens Pregnancy. 2012; 2011 Dec 9. PMID: 22150085

Silasi M, Rana S, Powe C, Cohen B, Lim KH, Zsengellér ZK, Karumanchi SA, Stillman IE: Placental expression of angiogenic factors in Trisomy 13. Am J Obstet Gynecol. 2011 Jun; 2011 Apr 20. PMID: 21507376

Kasper EM, Hess PE, Silasi M, Lim KH, Gray J, Reddy H, Gilmore L, Kasper B: A pregnant female with a large intracranial mass: Reviewing the evidence to obtain management guidelines for intracranial meningiomas during pregnancy. Surg Neurol Int. 2010 Dec 25; 2010 Dec 25. PMID: 21245945

Silasi M, Coonrod DV, Kim M, Drachman D: Transient tachypnea of the newborn: is labor prior to cesarean delivery protective? Am J Perinatol. 2010 Nov; 2010 May 19. PMID: 20486067

Silasi M, Cohen B, Karumanchi SA, Rana S: Abnormal placentation, angiogenic factors, and the pathogenesis of preeclampsia. Obstet Gynecol Clin North Am. 2010 Jun. PMID: 20685551