Dr. Silasi's Lab

Research Interests

alt text

1. Role of IP-10 in the mechanism of preterm labor after viral infection: IP-10 (also known as Interferon gamma-induced protein of 10kDa) is a chemoattractant for activated T-cells. It is secreted by monocytes, endothelial cells, and fibroblast cells. It is induced by interferon, and is clinically useful as a prognostic indicator for patients with Hepatitis C and HIV. In pregnancy, elevated amniotic fluid levels of IP-10 at midtrimester have been associated with preterm delivery before 32 weeks, while increased expression of IP-10 has been shown in placentas with histological chronic chorioamnionitis. A two-hit model of preterm labor and delivery has previously been developed in the lab, and IP-10 levels are seen to increase in correlation with the model.

alt text

2. Interaction between cell types at the maternal-fetal interface: The maternal-fetal interface is comprised of maternal decidua and immune cells interfaced with fetal trophoblast, immune, and endothelial cells. While much research has focused on the behavior of individual cells such as the trophoblast or maternal immune cells, little is known about how these cells interact with each other in order to maintain pregnancy success or during complications of pregnancy.

Silasi, Michelle

Principal Investigator

Assistant Professor of Obstetrics, Gynecology, and Reproductive Sciences

Publications

Racicot KE, Wünsche V, Auerbach B, Aldo P, Silasi M and Mor G: Human Chorionic Gonadotropin Enhances Trophoblast-Epithelial Interaction in an In Vitro Model of Human Implantation. Reprod Sci. 2014 Feb 11; Epub 2014 Feb 11. PMID: 24520082

Silasi DA, Gallo T, Silasi M, Menderes G and Azodi M: Robotic versus abdominal hysterectomy for very large uteri. JSLS. 2013 Jul-Sep;17 (3) :400-6. PMID: 24018076


Silasi M: Viral invasion of the amniotic cavity (VIAC) in the midtrimester of pregnancy. Am J Reprod Immunol. 2013 Mar;69 (3) :195-6. PMID: 23384234

Silasi M and Mor G: Decidual stromal cells as regulators of T-cell access to the maternal-fetal interface. Am J Reprod Immunol. 2012 Oct;68 (4) :279-81. Epub 2012 Aug 31. PMID: 22935072


Bixel K, Silasi M, Zelop CM, Lim KH, Zsengeller Z, Stillman IE and Rana S: Placental origins of angiogenic dysfunction in mirror syndrome. Hypertens Pregnancy. 2012;31 (2) :211-7. Epub 2011 Dec 9. PMID: 22150085

Silasi M, Rana S, Powe C, Cohen B, Lim KH, Zsengellér ZK, Karumanchi SA and Stillman IE: Placental expression of angiogenic factors in Trisomy 13. Am J Obstet Gynecol. 2011 Jun;204 (6) :546.e1-4. Epub 2011 Apr 20. PMID: 21507376

Kasper EM, Hess PE, Silasi M, Lim KH, Gray J, Reddy H, Gilmore L and Kasper B: A pregnant female with a large intracranial mass: Reviewing the evidence to obtain management guidelines for intracranial meningiomas during pregnancy. Surg Neurol Int. 2010 Dec 25;1 :95. Epub 2010 Dec 25. PMID: 21245945


Silasi M, Coonrod DV, Kim M and Drachman D: Transient tachypnea of the newborn: is labor prior to cesarean delivery protective? Am J Perinatol. 2010 Nov;27 (10) :797-802. Epub 2010 May 19. PMID: 20486067


Silasi M, Cohen B, Karumanchi SA and Rana S: Abnormal placentation, angiogenic factors, and the pathogenesis of preeclampsia. Obstet Gynecol Clin North Am. 2010 Jun;37 (2) :239-53. PMID: 20685551