Pregnancy


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Dr. Abrahams' Lab

Dr. Abrahams' lab studies Reproductive Immunology with a focus on the impact the immune system and immunological processes have on pregnancy outcome. Her research is concentrated on three main areas: 

1. Innate immune responses to infection at the maternal-fetal interface 
2. Mechanisms of antiphospholipid antibody-induced pregnancy complications
3. The role of placental microparticles in the pathogenesis of preeclampsia
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Dr. Guller's Lab

Research in Dr. Guller’s laboratory focuses on placental dysfunction in adverse preterm pregnancy outcomes including preeclampsia (PE), intrauterine growth restriction, and chorioamnionitis (CAM). The overall goal of his work is to elucidate the role of major cell types of the placental villus, including syncytiotrophoblast, Hofbauer cells (HBCs, fetal macrophages), fibroblasts, and fetal endothelial cells, in mediating responses to glucocorticoid, hypoxia-reperfusion injury, and intrauterine infection.

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Dr. Mor's Lab

The main interests of our laboratory are to examine the role of the immune system and inflammation in both pregnancy outcome as well as ovarian cancer formation.

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Dr. Mak's Lab

Dr. Mak has three main areas of research interest:

  1. Understanding the role of a translational regulator, Pumilio, in the acquisition of the primordial follicle pool, oocyte maturation and maternal-to-zygotic transition. These studies will elucidate the genes important in establishing the ovarian reserve in women and identify new biomarkers of oocyte and embryo quality. 

Dr. Silasi's Lab

Dr. Silasi is a Maternal-Fetal Medicine physician in the Section of Maternal-Fetal Medicine. Her research interests lie in the role of the immune system in complications of pregnancy, specifically preterm labor and preterm delivery. She currently is a WRHR scholar and is part of the Reproductive Immunology Unit.

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Reproductive Immunology Unit

The Reproductive Immunology Unit conducts studies that characterize the interaction between the immune system and reproductive organs with focus on two main areas of research: