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Dr. Abrahams' Lab

Dr. Abrahams' lab studies Reproductive Immunology with a focus on the impact the immune system and immunological processes have on pregnancy outcome. Her research is concentrated on three main areas: 

1. Innate immune responses to infection at the maternal-fetal interface 
2. Mechanisms of antiphospholipid antibody-induced pregnancy complications
3. The role of placental microparticles in the pathogenesis of preeclampsia
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Dr. Guller's Lab

Research in Dr. Guller’s laboratory focuses on placental dysfunction in adverse preterm pregnancy outcomes including preeclampsia (PE), intrauterine growth restriction, and chorioamnionitis (CAM). The overall goal of his work is to elucidate the role of major cell types of the placental villus, including syncytiotrophoblast, Hofbauer cells (HBCs, fetal macrophages), fibroblasts, and fetal endothelial cells, in mediating responses to glucocorticoid, hypoxia-reperfusion injury, and intrauterine infection.

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Dr. Johnson's Lab

Dr. Johnson's research program focuses on the control of oocyte number inside the ovary, primarily in mammals, but recently also in the fruit fly model organism. We are currently focused on mechanisms that support oocyte quality--the ability to give rise to a healthy offspring--and those that lead to oocyte loss, due to 'normal' aging and in the context of human premature ovarian failure (POF). To maximize his clinical/ translation acumen, Dr. Johnson was trained and worked part-time as an embryologist in the Yale IVF Center. Now, our primary mission is to better understand the function of the ovary so we can first identify women whose ovaries are at risk of failing or who will have trouble conceiving, and one day intervene to protect fertility and organ function.

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Dr. Mor's Lab

The main interests of our laboratory are to examine the role of the immune system and inflammation in both pregnancy outcome as well as ovarian cancer formation.

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Dr. Mak's Lab

Dr. Mak has three main areas of research interest:

  1. Understanding the role of a translational regulator, Pumilio, in the acquisition of the primordial follicle pool, oocyte maturation and maternal-to-zygotic transition. These studies will elucidate the genes important in establishing the ovarian reserve in women and identify new biomarkers of oocyte and embryo quality. 

Dr. Silasi's Lab

Dr. Silasi is a Maternal-Fetal Medicine physician in the Section of Maternal-Fetal Medicine. Her research interests lie in the role of the immune system in complications of pregnancy, specifically preterm labor and preterm delivery. She currently is a WRHR scholar and is part of the Reproductive Immunology Unit.

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Reproductive Immunology Unit

The Reproductive Immunology Unit conducts studies that characterize the interaction between the immune system and reproductive organs with focus on two main areas of research: