Dr. Taylor's Lab

Research Interests

Dr. Taylor's lab studies Reproductive Endocrinology with a focus on endometrial pathophysiology. Ongoing research focuses on the role of genetics, epigenetics, environmental disruptors in endometrial health and disease as well as stem cells in endometrial repair and tissue engineering

(1) Endometriosis: The Taylor lab has been studying genetics and epigenetics of endometriosis as well as the role of endocrine disruptors and stem cells in the development of this disease. Novel biomarkers and therapies for this disease are active areas of investigation.
(2) Endometrial Receptivity and Infertility: Endometriosis, Asherman’s syndrome, and Leiomyoma are major causes for infertility. The laboratory has identified several mechanisms responsible for altered receptivity and infertility as well as potential therapies.
(3) Uterine Development:We have identified a role for HOX genes in the developmental patterning of the uterus.  We currently study the molecular regulation of uterine development as well as the effects of environmental agents on the developmental programming.
(4) Uterine Stem Cells and Tissue Engineering: We have identified stem cells in the murine and human endometrium. Endogenous progenitor cells as well as bone marrow mesenchymal stem cells contribute to endometrial regeneration. In addition, we have identified a multipotent mesenchymal stem cell population in the endometrium. These cells are can be isolated and useful in tissue engineering.  This readily available and immunologically matched source of cells holds great therapeutic promise for women.
(5) Menopause: We have conducted clinical and translational studies on the role of estrogens, progestins and SERMs in menopausal women.  A particular interest of our group is the effects of these agents on the uterus, skin, heart and brain.

Taylor, Hugh S.

Principal Investigator

Anita O'Keeffe Young Professor of Obstetrics, Gynecology, and Reproductive Sciences and Professor of Molecular, Cellular, and Developmental Biology
Chief of Obstetrics and Gynecology, Yale-New Haven Hospital
Anita O'Keeffe Young Professor of Women's Health, Yale University

Research Interests:Endometriosis; Stem Cells; Embryo Implantation; Asherman's Syndrome; Menopause; Uterine Development; Endorcrine Disruption; Developmental Programming

Clinical Interests:Infertility; In Vitro Fertilization (IVF); Reproductive surgery; Congenital anomalies; Diethylstilbesterol (DES) exposure; Implantation/endometrial receptivity; Endometriosis; Menopause; Polycystic Ovarian Syndrome (PCOS); Recurrent pregnancy loss (1st trimester); Fibroids; Asherman's syndrome

  • Office:(203) 785-4001
  • Appt:(203) 785-4708

Choe, Gina

Postgraduate Associate in Obstetrics, Gynecology, and Reproductive Sciences

Du, Hongling

Associate Research Scientist in Obstetrics, Gynecology, and Reproductive Sciences

Krikun, Graciela

Research Scientist in Obstetrics, Gynecology, and Reproductive Sciences

Research Interests:Endometrial hemostasis; Angiogenesis; Endometrial immune response; Endometriosis.

Mutlu, Levent

Postdoctoral Fellow in Obstetrics, Gynecology, and Reproductive Sciences

Neisani Samani, Elham

Postdoctoral Fellow in Obstetrics, Gynecology, and Reproductive Sciences

Publications

Naqvi H, Sakr S, Presti T, Krikun G, Komm B and Taylor HS: Treatment with bazedoxifene and conjugated estrogens results in regression of endometriosis in a murine model. Biol Reprod. 2014 Jun;90 (6) :121. Epub 2014 Apr 16. PMID: 24740602


Santen RJ, Kagan R, Altomare CJ, Komm B, Mirkin S and Taylor HS: Current and evolving approaches to individualizing estrogen receptor-based therapy for menopausal women. J Clin Endocrinol Metab. 2014 Mar;99 (3) :733-47. Epub 2014 Jan 1. PMID: 24423357


Kanimozhi V, Palanivel K, Kadalmani B, Krikun G and Taylor HS: Apolipoprotein E Induction in Syrian Hamster Testis Following Tributyltin Exposure: A Potential Mechanism of Male Infertility. Reprod Sci. 2014 Feb 10;21 (8) :1006-1014. Epub 2014 Feb 10. PMID: 24516040

Macer ML and Taylor HS: Endometriosis and infertility: a review of the pathogenesis and treatment of endometriosis-associated infertility. Obstet Gynecol Clin North Am. 2012 Dec;39 (4) :535-49. PMID: 23182559


Taylor HS and Ohleth K: Using bazedoxifene plus conjugated estrogens for treating postmenopausal women: a comprehensive review. Menopause. 2012 Apr;19 (4) :479-85. PMID: 22278343

Petracco R, Grechukhina O, Popkhadze S, Massasa E, Zhou Y and Taylor HS: MicroRNA 135 regulates HOXA10 expression in endometriosis. J Clin Endocrinol Metab. 2011 Dec;96 (12) :E1925-33. Epub 2011 Sep 28. PMID: 21956427


Zhou Y, Jorgensen EM, Gan Y and Taylor HS: Cigarette smoke increases progesterone receptor and homeobox A10 expression in human endometrium and endometrial cells: a potential role in the decreased prevalence of endometrial pathology in smokers. Biol Reprod. 2011 Jun;84 (6) :1242-7. Epub 2011 Feb 16. PMID: 21325691

Odom LN and Taylor HS: Environmental induction of the fetal epigenome. Expert Rev Obstet Gynecol. 2010 Nov 1;5 (6) :657-664. PMID: 21297874