Dr. Taylor's Lab

Research Interests

Dr. Taylor's lab studies Reproductive Endocrinology with a focus on endometrial pathophysiology. Ongoing research focuses on the role of genetics, epigenetics, environmental disruptors in endometrial health and disease as well as stem cells in endometrial repair and tissue engineering

(1) Endometriosis: The Taylor lab has been studying genetics and epigenetics of endometriosis as well as the role of endocrine disruptors and stem cells in the development of this disease. Novel biomarkers and therapies for this disease are active areas of investigation.
(2) Endometrial Receptivity and Infertility: Endometriosis, Asherman’s syndrome, and Leiomyoma are major causes for infertility. The laboratory has identified several mechanisms responsible for altered receptivity and infertility as well as potential therapies.
(3) Uterine Development:  We have identified a role for HOX genes in the developmental patterning of the uterus.  We currently study the molecular regulation of uterine development as well as the effects of environmental agents on the developmental programming.
(4) Uterine Stem Cells and Tissue Engineering: We have identified stem cells in the murine and human endometrium. Endogenous progenitor cells as well as bone marrow mesenchymal stem cells contribute to endometrial regeneration. In addition, we have identified a multipotent mesenchymal stem cell population in the endometrium. These cells are can be isolated and useful in tissue engineering.  This readily available and immunologically matched source of cells holds great therapeutic promise for women.
(5) Menopause: We have conducted clinical and translational studies on the role of estrogens, progestins and SERMs in menopausal women.  A particular interest of our group is the effects of these agents on the uterus, skin, heart and brain.

Lab Members

Bio Profile

Hugh S. Taylor, MD

Principal Investigator

Anita O'Keeffe Young Professor of Obstetrics, Gynecology, and Reproductive Sciences and Professor of Molecular, Cellular, and Developmental Biology

Chair of Obstetrics, Gynecology, and Reproductive Sciences, Yale School of Medicine

Chief of Obstetrics and Gynecology, Yale-New Haven Hospital

Clinical Interests

Endometriosis; Infertility; Menopause; Menstruation Disturbances

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Graciela Krikun, PhD

Research Scientist in Obstetrics, Gynecology, and Reproductive Sciences

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Levent Mutlu, MD

PGY-1 Resident Ob/Gyn

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Babayev E, Wang T, Szigeti-Buck K, Lowther K, Taylor HS, Horvath T, Seli E: Reproductive aging is associated with changes in oocyte mitochondrial dynamics, function, and mtDNA quantity. Maturitas. 2016 Nov; 2016 Jun 23. PMID: 27523387

Moridi I, Mamillapalli R, Cosar E, Ersoy GS, Taylor HS: Bone Marrow Stem Cell Chemotactic Activity Is Induced by Elevated CXCl12 in Endometriosis. Reprod Sci. 2016 Oct 11; 2016 Oct 11. PMID: 27729562

Tal R, Liu Y, Pluchino N, Shaikh S, Mamillapalli R, Taylor HS: A Murine 5-Fluorouracil-Based Submyeloablation Model for the Study of Bone Marrow-Derived Cell Trafficking in Reproduction. Endocrinology. 2016 Oct; 2016 Jul 18. PMID: 27427897

Flannery CA, Fleming AG, Choe GH, Naqvi H, Zhang M, Sharma A, Taylor HS: Endometrial Cancer-Associated FGF18 Expression Is Reduced by Bazedoxifene in Human Endometrial Stromal Cells In Vitro and in Murine Endometrium. Endocrinology. 2016 Oct; 2016 Jun 6. PMID: 27267714

Seifer BJ, Su D, Taylor HS: Circulating miRNAs in Murine Experimental Endometriosis: Decreased Abundance of let-7a. Reprod Sci. 2016 Sep 21; 2016 Sep 21. PMID: 27655771

Cho S, Mutlu L, Zhou Y, Taylor HS: Aromatase inhibitor regulates let-7 expression and let-7f-induced cell migration in endometrial cells from women with endometriosis. Fertil Steril. 2016 Sep 1; 2016 Jun 16. PMID: 27320036

Taylor HS, Kagan R, Altomare CJ, Cort S, Bushmakin AG, Abraham L: Knowledge of clinical trials regarding hormone therapy and likelihood of prescribing hormone therapy. Menopause. 2016 Aug 29; 2016 Aug 29. PMID: 27575548

Cosar E, Mamillapalli R, Ersoy GS, Cho S, Seifer B, Taylor HS: Serum microRNAs as diagnostic markers of endometriosis: a comprehensive array-based analysis. Fertil Steril. 2016 Aug; 2016 May 11. PMID: 27179784

Fischer C, Mamillapalli R, Goetz LG, Jorgenson E, Ilagan Y, Taylor HS: Bisphenol A (BPA) Exposure In Utero Leads to Immunoregulatory Cytokine Dysregulation in the Mouse Mammary Gland: A Potential Mechanism Programming Breast Cancer Risk. Horm Cancer. 2016 Aug; 2016 Feb 24. PMID: 26911702

Flannery CA, Saleh FL, Choe GH, Selen DJ, Kodaman PH, Kliman HJ, Wood TL, Taylor HS: Differential Expression of IR-A, IR-B and IGF-1R in Endometrial Physiology and Distinct Signature in Adenocarcinoma. J Clin Endocrinol Metab. 2016 Jul; 2016 Apr 18. PMID: 27088794

Flannery CA, Rowzee AM, Choe GH, Saleh FL, Radford CC, Taylor HS, Wood TL: Development of a Quantitative PCR Assay for Detection of Human Insulin-Like Growth Factor Receptor and Insulin Receptor Isoforms. Endocrinology. 2016 Apr; 2016 Feb 10. PMID: 26862994

Kulp JL, Mamillapalli R, Taylor HS: Aberrant HOXA10 Methylation in Patients With Common Gynecologic Disorders: Implications for Reproductive Outcomes. Reprod Sci. 2016 Apr; 2016 Feb 10. PMID: 26865543

Naqvi H, Mamillapalli R, Krikun G, Taylor HS: Endometriosis Located Proximal to or Remote From the Uterus Differentially Affects Uterine Gene Expression. Reprod Sci. 2016 Feb; 2015 Oct 28. PMID: 26516123

Parker W, Berek JS, Pritts E, Olive D, Kaunitz AM, Chalas E, Clarke-Pearson D, Goff B, Bristow R, Taylor HS, Farias-Eisner R, Fader AN, Maxwell GL, Goodwin SC, Love S, Gibbons WE, Foshag LJ, Leppert PC, Norsigian J, Nager CW, Johnson T, Guzick DS, As-Sanie S, Paulson RJ, Farquhar C, Bradley L, Scheib SA, Bilchik AJ, Rice LW, Dionne C, Jacoby A, Ascher-Walsh C, Kilpatrick SJ, Adamson GD, Siedhoff M, Israel R, Paraiso MF, Frumovitz MM, Lurain JR, Al-Hendy A, Benrubi GI, Raman SS, Kho RM, Anderson TL, Reynolds RK, DeLancey J: An Open Letter to the Food and Drug Administration Regarding the Use of Morcellation Procedures in Women Having Surgery for Presumed Uterine Myomas. J Minim Invasive Gynecol. 2016 Mar-Apr; 2016 Jan 8. PMID: 26773577

Zhou J, Yang L, Zhong T, Mueller M, Men Y, Zhang N, Xie J, Giang K, Chung H, Sun X, Lu L, Carmichael GG, Taylor HS, Huang Y: H19 lncRNA alters DNA methylation genome wide by regulating S-adenosylhomocysteine hydrolase. Nat Commun. 2015 Dec 21; 2015 Dec 21. PMID: 26687445

Yang H, Kang K, Cheng C, Mamillapalli R, Taylor HS: Integrative Analysis Reveals Regulatory Programs in Endometriosis. Reprod Sci. 2015 Sep; 2015 Jun 30. PMID: 26134036

Hufnagel D, Li F, Cosar E, Krikun G, Taylor HS: The Role of Stem Cells in the Etiology and Pathophysiology of Endometriosis. Semin Reprod Med. 2015 Sep; 2015 Sep 16. PMID: 26375413

Wenner MM, Taylor HS, Stachenfeld NS: Peripheral Microvascular Vasodilatory Response to Estradiol and Genistein in Women with Insulin Resistance. Microcirculation. 2015 Jul. PMID: 25996650

Wang X, Mamillapalli R, Mutlu L, Du H, Taylor HS: Chemoattraction of bone marrow-derived stem cells towards human endometrial stromal cells is mediated by estradiol regulated CXCL12 and CXCR4 expression. Stem Cell Res. 2015 Jul; 2015 Apr 24. PMID: 25957946

Ghazal S, McKinnon B, Zhou J, Mueller M, Men Y, Yang L, Mueller M, Flannery C, Huang Y, Taylor HS: H19 lncRNA alters stromal cell growth via IGF signaling in the endometrium of women with endometriosis. EMBO Mol Med. 2015 Jun 18; 2015 Jun 18. PMID: 26089099

Mutlu L, Hufnagel D, Taylor HS: The endometrium as a source of mesenchymal stem cells for regenerative medicine. Biol Reprod. 2015 Jun; 2015 Apr 22. PMID: 25904012

Cho S, Mutlu L, Grechukhina O, Taylor HS: Circulating microRNAs as potential biomarkers for endometriosis. Fertil Steril. 2015 May; 2015 Mar 13. PMID: 25772772

Taylor HS: The role of EMX2 in uterine development. Fertil Steril. 2015 Mar; 2015 Jan 27. PMID: 25637477

Doherty LF, Taylor HS: Leiomyoma-derived transforming growth factor-β impairs bone morphogenetic protein-2-mediated endometrial receptivity. Fertil Steril. 2015 Mar; 2015 Jan 14. PMID: 25596622

Wolff EF, Mutlu L, Massasa EE, Elsworth JD, Eugene Redmond D Jr, Taylor HS: Endometrial stem cell transplantation in MPTP- exposed primates: an alternative cell source for treatment of Parkinson's disease. J Cell Mol Med. 2015 Jan; 2014 Oct 6. PMID: 25283241

Naqvi H, Sakr S, Presti T, Krikun G, Komm B, Taylor HS: Treatment with bazedoxifene and conjugated estrogens results in regression of endometriosis in a murine model. Biol Reprod. 2014 Jun; 2014 Apr 16. PMID: 24740602

Santen RJ, Kagan R, Altomare CJ, Komm B, Mirkin S, Taylor HS: Current and evolving approaches to individualizing estrogen receptor-based therapy for menopausal women. J Clin Endocrinol Metab. 2014 Mar; 2014 Jan 1. PMID: 24423357

Kanimozhi V, Palanivel K, Kadalmani B, Krikun G, Taylor HS: Apolipoprotein E Induction in Syrian Hamster Testis Following Tributyltin Exposure: A Potential Mechanism of Male Infertility. Reprod Sci. 2014 Feb 10; 2014 Feb 10. PMID: 24516040

Petracco R, Grechukhina O, Popkhadze S, Massasa E, Zhou Y, Taylor HS: MicroRNA 135 regulates HOXA10 expression in endometriosis. J Clin Endocrinol Metab. 2011 Dec; 2011 Sep 28. PMID: 21956427

Zhou Y, Jorgensen EM, Gan Y, Taylor HS: Cigarette smoke increases progesterone receptor and homeobox A10 expression in human endometrium and endometrial cells: a potential role in the decreased prevalence of endometrial pathology in smokers. Biol Reprod. 2011 Jun; 2011 Feb 16. PMID: 21325691

Odom LN, Taylor HS: Environmental induction of the fetal epigenome. Expert Rev Obstet Gynecol. 2010 Nov 1. PMID: 21297874