Dr. Taylor's lab studies Reproductive Endocrinology with a focus on endometrial pathophysiology. Ongoing research focuses on the role of genetics, epigenetics, environmental disruptors in endometrial health and disease as well as stem cells in endometrial repair and tissue engineering
(1) Endometriosis: The Taylor lab has been studying genetics and epigenetics of endometriosis as well as the role of endocrine disruptors and stem cells in the development of this disease. Novel biomarkers and therapies for this disease are active areas of investigation.
(2) Endometrial Receptivity and Infertility: Endometriosis, Asherman’s syndrome, and Leiomyoma are major causes for infertility. The laboratory has identified several mechanisms responsible for altered receptivity and infertility as well as potential therapies.
(3) Uterine Development: We have identified a role for HOX genes in the developmental patterning of the uterus. We currently study the molecular regulation of uterine development as well as the effects of environmental agents on the developmental programming.
(4) Uterine Stem Cells and Tissue Engineering: We have identified stem cells in the murine and human endometrium. Endogenous progenitor cells as well as bone marrow mesenchymal stem cells contribute to endometrial regeneration. In addition, we have identified a multipotent mesenchymal stem cell population in the endometrium. These cells are can be isolated and useful in tissue engineering. This readily available and immunologically matched source of cells holds great therapeutic promise for women.
(5) Menopause: We have conducted clinical and translational studies on the role of estrogens, progestins and SERMs in menopausal women. A particular interest of our group is the effects of these agents on the uterus, skin, heart and brain.
Anita O'Keeffe Young Professor of Obstetrics, Gynecology, and Reproductive Sciences and Professor of Molecular, Cellular, and Developmental Biology
Chair of Obstetrics, Gynecology, and Reproductive Sciences, Yale School of Medicine
Chief of Obstetrics and Gynecology, Yale-New Haven Hospital
Endometriosis; Infertility; Menopause; Menstruation Disturbances