Dr. Mak's Lab

Research Interests

Dr. Mak has three main areas of research interest:

  1. Understanding the role of a translational regulator, Pumilio, in the acquisition of the primordial follicle pool, oocyte maturation and maternal-to-zygotic transition. These studies will elucidate the genes important in establishing the ovarian reserve in women and identify new biomarkers of oocyte and embryo quality. 
  2. Understanding the pathophysiology of recurrent pregnancy loss (RPL) using molecular techniques to investigate the epigenetics i.e. DNA methylation patterns of these losses. These studies will expand our limited knowledge of the etiology of these conditions. Furthermore, these studies will lead to the discovery of new therapeutic targets for these conditions. 
  3. Investigating the potential of trophoblast stem cells to be used in regeneration and therapy for the placenta, akin to the use of embryonic stem cells for regenerative medicine in somatic tissues. These studies will lead potentially to a novel therapeutic strategy for conditions ranging from RPL to preeclampsia.

Mak, Winifred

Assistant Professor of Obstetrics, Gynecology, and Reproductive Sciences; Director, Early Recurrent Pregnancy Loss Program

Biography

Dr. Winifred Mak is an Assistant Professor of Obstetrics and Gynecology at Yale University and Director of Early Recurrent Pregnancy Loss Program. She obtained both of her medical degree and PhD in Genetics from the University of London, UK. She completed her Residency in Obstetrics and Gynecology at Cedars-Sinai medical center, Los Angeles followed by a fellowship in Reproductive Endocrinology and Infertility at the University of Pennsylvania. After graduating from fellowship, she was...

Dr. Winifred Mak is an Assistant Professor of Obstetrics and Gynecology at Yale University and Director of Early Recurrent Pregnancy Loss Program. She obtained both of her medical degree and PhD in Genetics from the University of London, UK. She completed her Residency in Obstetrics and Gynecology at Cedars-Sinai medical center, Los Angeles followed by a fellowship in Reproductive Endocrinology and Infertility at the University of Pennsylvania. After graduating from fellowship, she was recruited to Yale University to be one of the Women’s Reproductive Health Research (WRHR) scholars. The WRHR program is a nationwide prestigious NIH funded physician-scientist training program specific for Obstetrician/Gynecologist. Therefore, as well as caring for patients, she also has an active research program at the Yale Stem Cell Center. Her clinical interests include all aspects of Infertility, polycystic ovarian syndrome and especially recurrent pregnancy loss. Her research interests include the role of a translational regulator, Pumilio, in primordial folliculogenesis and oogenesis, epigenetics of placenta development, placental stem cells, embryo implantation and pregnancy outcomes of Assisted Reproductive Technologies such as IVF.

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Fang, Caodi

Research Assistant Ob/Gyn