Dr. Flannery is interested in the effect of insulin resistance and diabetes on endometrial pathology. Insulin resistance is an underlying problem in obesity, the Polycystic Ovary Syndrome, and Type 2 diabetes mellitus. Women with obesity, PCOS, or Type 2 diabetes mellitus have a higher risk of irregular bleeding, implantation failure, miscarriage, endometrial hyperplasia, and endometrial carcinoma.
Dr. Huang’s research interest has been the post-transcriptional regulation of gene expression in the mammalian system. While studying the rules and mechanisms that govern the nucleocytoplasmic transport of mRNAs, she discovered that a subset of SR proteins (originally thought to be only splicing factors) function as a new class of mRNA export factors.
Dr. Johnson's research program focuses on the control of oocyte number inside the ovary, primarily in mammals, but recently also in the fruit fly model organism. We are currently focused on mechanisms that support oocyte quality--the ability to give rise to a healthy offspring--and those that lead to oocyte loss, due to 'normal' aging and in the context of human premature ovarian failure (POF). To maximize his clinical/ translation acumen, Dr. Johnson was trained and worked part-time as an embryologist in the Yale IVF Center. Now, our primary mission is to better understand the function of the ovary so we can first identify women whose ovaries are at risk of failing or who will have trouble conceiving, and one day intervene to protect fertility and organ function.
The Seli lab's main research interests are:1. Regulation of gene expression during oocyte and pre-implantation embryo development
2. Assessment of embryo viability in assisted reproductive technologies
3. The role of translational regulation of cytokine and growth factor expression in the pathogenesis of endometriosis
Dr. Taylor's lab studies Reproductive Endocrinology with a focus on endometrial pathophysiology. Ongoing research focuses on the role of genetics, epigenetics, environmental disruptors in endometrial health and disease as well as stem cells in endometrial repair and tissue engineering