Dr. Flannery's Lab

Research Interests

Dr. Flannery is interested in the effect of insulin resistance and diabetes on endometrial pathology. Insulin resistance is an underlying problem in obesity, the Polycystic Ovary Syndrome, and Type 2 diabetes mellitus. Women with obesity, PCOS, or Type 2 diabetes mellitus have a higher risk of irregular bleeding, implantation failure, miscarriage, endometrial hyperplasia, and endometrial carcinoma. Dr. Flannery’s research aims to determine whether this endometrial dysfunction is a consequence of the metabolic abnormalities occurring in insulin resistance. Using techniques in molecular biology, she examines potential mechanisms for how insulin and glucose affect epithelial cell proliferation and stromal cell decidualization in the endometrium. The Flannery lab studies type 2 Diabetes Mellitus, Polycystic Ovary Syndrome, Endometrial cancer and Endometrial factors in early pregnancy loss.

Lab Members


Bio Profile

Clare Ann Flannery

Principal Investigator

Assistant Professor of Obstetrics, Gynecology, and Reproductive Sciences (Reproductive Endocrinology) and of Medicine (Endocrinology)

Georgia Holland

Senior Undergraduate Thesis Student

Farrah Saleh

Senior Undergraduate Student

Margaret Zhang

Senior Undergraduate Thesis Student

Publications

Ghazal S, McKinnon B, Zhou J, Mueller M, Men Y, Yang L, Mueller M, Flannery C, Huang Y, Taylor HS: H19 lncRNA alters stromal cell growth via IGF signaling in the endometrium of women with endometriosis. EMBO Mol Med. 2015 Jun 18; 2015 Jun 18. PMID: 26089099

Han CS, Herrin MA, Pitruzzello MC, Mulla MJ, Werner EF, Pettker CM, Flannery CA, Abrahams VM: Glucose and metformin modulate human first trimester trophoblast function: a model and potential therapy for diabetes-associated uteroplacental insufficiency. Am J Reprod Immunol. 2015 Apr; 2014 Nov 14. PMID: 25394884

Gao Y, Wu F, Zhou J, Yan L, Jurczak MJ, Lee HY, Yang L, Mueller M, Zhou XB, Dandolo L, Szendroedi J, Roden M, Flannery C, Taylor H, Carmichael GG, Shulman GI, Huang Y: The H19/let-7 double-negative feedback loop contributes to glucose metabolism in muscle cells. Nucleic Acids Res. 2014 Dec 16; 2014 Nov 15. PMID: 25399420

Karalok HM, Aydin E, Saglam O, Torun A, Guzeloglu-Kayisli O, Lalioti MD, Kristiansson H, Duke CM, Choe G, Flannery C, Kallen CB, Seli E: mRNA-binding protein TIA-1 reduces cytokine expression in human endometrial stromal cells and is down-regulated in ectopic endometrium. J Clin Endocrinol Metab. 2014 Dec. PMID: 25140393

Flannery CA, Rackow B, Cong X, Duran E, Selen DJ, Burgert TS: Polycystic ovary syndrome in adolescence: impaired glucose tolerance occurs across the spectrum of BMI. Pediatr Diabetes. 2013 Feb; 2012 Aug 28. PMID: 22925367

Flannery C, Dufour S, Rabøl R, Shulman GI, Petersen KF: Skeletal muscle insulin resistance promotes increased hepatic de novo lipogenesis, hyperlipidemia, and hepatic steatosis in the elderly. Diabetes. 2012 Nov; 2012 Jul 24. PMID: 22829450

Rabøl R, Petersen KF, Dufour S, Flannery C, Shulman GI: Reversal of muscle insulin resistance with exercise reduces postprandial hepatic de novo lipogenesis in insulin resistant individuals. Proc Natl Acad Sci U S A. 2011 Aug 16; 2011 Aug 1. PMID: 21808028

Erion DM, Ignatova ID, Yonemitsu S, Nagai Y, Chatterjee P, Weismann D, Hsiao JJ, Zhang D, Iwasaki T, Stark R, Flannery C, Kahn M, Carmean CM, Yu XX, Murray SF, Bhanot S, Monia BP, Cline GW, Samuel VT, Shulman GI: Prevention of hepatic steatosis and hepatic insulin resistance by knockdown of cAMP response element-binding protein. Cell Metab. 2009 Dec. PMID: 19945407