Research

The research agenda within Discovery to Cure focuses on translational scientific investigation, which forms a bridge between the laboratory and the clinic and continually delivers the most up-to-date treatment options available to patients.

In collaboration with the Yale Gynecologic Oncology Group, the Discovery to Cure Program identifies novel treatments for ovarian cancer, which includes the development of early detection screening tests that enable physicians to detect ovarian cancer in its early stages when it is highly curable, and developing disease markers that can predict the response to chemotherapy and therefore help determine the best method of treatment of women diagnosed with the disease.

Programs of Research:

• Ovarian
• Endometrial
• Uterine
• Cervical

• TRX-E-001-1 Induces c-Jun-Dependent Apoptosis in Ovarian Cancer Stem Cells and Prevents Recurrence In Vivo
  
• Ovulation and extra-ovarian origin of ovarian cancer
• Prevalence of Epithelial Ovarian Cancer Stem Cells Correlates with Recurrence in Early-Stage Ovarian Cancer
• Ovarian cancer stem cells and inflammation
• 7-(O)-Carboxymethyl daidzein conjugated to N-t-Boc-hexylenediamine
• Targeting the Mitochondria Activates Two Independent Cell Death Pathways in Ovarian Cancer Stem Cells
• TLR2 enhances ovarian cancer stem cell self-renewal and promotes tumor repair and recurrence
• Multiple blocks in the engagement of oxidative phosphorylation in putative ovarian cancer stem cells: implication for maintenance therapy with glycolysis inhibitors
• Phenotypic modifications in ovarian cancer stem cells following Paclitaxel treatment
• Inhibition of Aurora-A kinase induces cell cycle arrest in epithelial ovarian cancer stem cells by affecting NFκB pathway
• Development and Validation of a Protein-based Signature for the Detection of Ovarian Cancer
• Regulation of Inflammation by the NF-jB Pathway in Ovarian Cancer Stem Cells
• Enhanced Stimulation of Anti-Ovarian Cancer CD8+ T Cells by Dendritic Cells Loaded with Nanoparticle Encapsulated Tumor Antigen
• Distinct Subpopulations of Epithelial Ovarian Cancer Cells Can Differentially Induce Macrophages and T Regulatory Cells Toward a Pro-Tumor Phenotype
• Multimodality Animal Rotation Imaging System (MARS) for In Vivo Detection of Intraperitoneal Tumors
• p53 protein aggregation promotes platinum resistance in ovarian cancer
• The Duplicitous Origin of Ovarian Cancer
• Stem-Like Ovarian Cancer Cells Can Serve as Tumor Vascular Progenitors
• Triapine (3-aninopyridine-2-carboxaldehyde thiosemicarbazone) Induces Apoptosis in Ovarian Cancer Cells