The Department of Obstetrics, Gynecology and Reproductive Sciences at Yale seeks to distinguish itself across all areas of our clinical, educational, and research mission areas. In our clinical care, we pride ourselves on providing our patients with all the benefits of academic medicine in newly remodeled, comfortable and pleasant clinical practice settings. We also focus intently on patient satisfaction and safety. Our Ob/Gyn physicians and physician scientists are renowned experts in their respective fields. They have advanced the practice of modern obstetrics and gynecology and pioneered many viable new treatments currently in use today, including:
- Developing the first In Vitro Fertilization program in the Northeast;
- Inventing fetal monitoring;
- Dramatically enhancing fetal echocardiography; and
- Developing key chemotherapy drugs for gynecologic cancers.
We complement our clinical care with a comprehensive clinical research program. Examples of our innovation in clinical research include:
- A new emphasis on therapeutic vaccines in Gynecologic Oncology;
- A comprehensive Patient Safety Program in Maternal-Fetal Medicine;
- A trial of a novel device addressing sexual dysfunction for our Urogynecology and Reconstructive Pelvic Surgery patients; and
- A pilot study of vitamin D therapy to address fertility issues in our patients suffering from Polycystic Ovarian Syndrome in Reproductive Endocrinology and Infertility.
Our research groups conduct their investigations into all areas of Reproductive Sciences, covering both basic and translational laboratory research, in modern, newly renovated research space. We are making important discoveries in the following areas of reproductive health research:
- Cancer Biology: Aberrant expression or regulation of steroid hormone receptors, the epidermal growth factor receptor, and cell signaling proteins in ovarian, breast, and uterine cancer.
- Reproductive Neurosciences: Learning and memory effects of xenoestrogens, such as the prevalent packaging compound bisphenol A (BPA); gut and peripheral hormone influences on wakefulness and excessive feeding behaviors; and estrogenic influences on synaptic function.
- Reproductive Physiology: Aberrant signaling pathways in polycystic ovarian syndrome; the etiology and regulation of endometriosis; characterization of uterine stem cells; and the endocrine regulation of reproductive tract gene expression.
- Maternal-Fetal Sciences: The interaction of uterine, placental and immune cells in the etiology and pathophysiology of preterm delivery, preeclampsia, and intrauterine growth restriction; proteomic and gene array methodologies to identify novel markers of prematurity and preeclampsia; and the role of extracellular matrix remodeling in the placenta and myometrium.
- Gamete Biology: Translational control of gene expression in the mammalian oocyte and early embryos; stress and nutrition pathways controlling the growth and death rates of ovarian follicles; and paternal effects on reproductive outcome.
Training Future Leaders in Women’s Health
We continue to offer a wide variety of training programs for reproductive physician scientists so that our current faculty’s reputation for inspired research will continue as we develop a new generation of reproductive health scientists.
Our mission in the area of education is to train the next generation of leaders in women’s health. We begin this process with a competitive summer internship program at the high school level, and continue it through active mentoring of our junior and mid-level faculty. For our medical students, the Ob/Gyn Clerkship is one of Yale’s top-rated clinical rotations. We go on to recruit and train highly qualified and dedicated physicians into our residency and subspecialty fellowship training programs.
We strive to be the very best academic department of Ob/Gyn in the country, a goal that keeps us all very busy and focused on excellence in Women’s Health.