Amygdala; Neuropharmacology; Neurophysiology; Social Behavior; Prefrontal Cortex; Psychiatry and Psychology
How do we interact with others, and why? Human and nonhuman primate brains have evolved to deal with increasing demands of dynamic social interactions. Social behaviors are heavily reinforcement driven, whether their motivating factors are physical rewards, such as food and sex, or more abstract rewards, such as vicarious experience and interpersonal reputation. Investigating how the brain computes social preferences and decisions can offer an ecologically valid and efficient way of unlocking the mystery of the mind. Elucidating the neural basis of social behavior will ultimately help treat social deficits in numerous psychiatric disorders.
My research is aimed at understanding the neural mechanisms responsible for social cognition. My laboratory focuses on how reward-related areas of the brain signal social preferences and generate social decisions. To answer our questions, we apply both neurophysiological and neuroendocrinological approaches while nonhuman primates are actively engaged in social interactions. We investigate neuronal representations as well as neuromodulatory actions of hormones, like oxytocin, in the reward-related brain regions during social behavior. We also study fundamental aspects of reward-guided decision-making in order to better understand how basic neural mechanisms are recruited to mediate social behavior.
Please feel free to contact me with any questions.
- Neural mechanisms of social interaction and social decision-making
- single-unit recording from primate prefrontal cortex
- posterior parietal cortex and basal ganglia
- neurobiology of oxytocin-mediated social cognition
- combined neurophysiology and neuropharmacology
- reference frames
- sensory-to-motor transformation
- neuroethology of social behavior
- Chang SW, Gariépy JF and Platt ML (2013) Neuronal reference frames for social decisions in primate frontal cortex. Nat. Neurosci., 16: 243–250.
- Chang SW, Barter JW, Ebitz RB, Watson KK and Platt ML (2012) Inhaled oxytocin amplifies both vicarious reinforcement and self reinforcement in rhesus macaques (Macaca mulatta). Proc. Natl. Acad. Sci., 109, 959–964.
- Chang SW, Brent LJN, Adams GK, Klein JT, Pearson JM, Watson KK, and Platt ML (2013) Neuroethology of primate social behavior. Proc. Natl. Acad. Sci., 110, 10387–10394.
- Chang SW, Winecoff AA, and Platt ML (2011) Vicarious reinforcement in rhesus macaques (Macaca mulatta). Front. Neurosci., 5, 27.
- Chang SW and Snyder LH (2010) Idiosyncratic and systematic aspects of spatial representations in the macaque parietal cortex. Proc. Natl. Acad. Sci., 107, 7951–7956.
- Chang SW, Papadimitriou C, and Snyder LH (2009) Using a compound gain field to compute a reach plan. Neuron, 64, 744–755.
- Chang SW, Dickinson AR and Snyder LH (2008) Limb-specific representations of reaching in the posterior parietal cortex. J. Neurosci., 28, 6128–6140.
- Chang SW (2013) Coordinate transformation approach to social interactions. Front. Neurosci.. 7, Article 147.
- Chang SW and Platt ML (in press) Oxytocin and social cognition in rhesus macaques: Implications for understanding and treating human psychopathology. Brain Research Special Issue on Oxytocin, Social Cognition and Psychopathology.
- Churchland MM, Yu BM, Cunningham JP, Sugrue LP, Cohen MR, Corrado GS, Newsome WT, Clark AM, Hosseini P, Scott BB, Bradley DC, Smith MA, Kohn A, Movshon JA, Armstrong KM, Moore T, Chang SW, Snyder LH, Lisberger SG, Priebe NJ, Finn IM, Ferster D, Ryu, SI, Santhanam G, Sahani M, and Shenoy KV (2010) Stimulus onset quenches neural variability: a widespread cortical phenomenon. Nat. Neurosci.,13, 369–378.
- Neural mechanisms of social decision-making in the primate amygdala Chang, S. W., Fagan, N. A., Toda, K., Utevsky, A. V., Pearson, J. M., & Platt, M. L. (2015). Neural mechanisms of social decision-making in the primate amygdala. Proceedings of the National Academy of Sciences, 201514761.