James R Howe PhD

Professor of Pharmacology

Departments & Organizations

Yale Combined Program in the Biological and Biomedical Sciences (BBS): Neuroscience | Biochemistry, Biophysics and Structural Biology

Office of Student ResearchInterdepartmental Neuroscience ProgramMembrane Proteins - Ion Channels | Membrane Biophysics | Membrane Protein Structure | Neurobiology and Physiology of Synapses | Physiology and Integrative Medical Biology Track | Graduate Program in Cellular and Molecular Physiology | Pharmacology: Neuropharmacology

Research Interests

Glutamate receptors more...


  • B.A., University of Minnesota, 1980
  • Ph.D., University of Minnesota, 1983

Selected Publications

  • Straub, C., Zhang, W. & Howe, J.R (2011). Neto2 modulation of kainate receptors with different subunit compositions. J. Neurosci. 31: 8078-8082.
  • Morimoto-Tomita, M., Zhang, W., Cho, C.-H., Kim, K.S., Straub, C., Howe, J.R. & Tomita, S. (2009) Auto-inactivation of neuronal AMPA receptors via glutamate-regulated TARP interaction. Neuron 61, 101-112.
  • Zhang, W., St-Gelais, F., Grabner, C.P., Trinidad, J.C., Sumioka, A., Morimoto-Tomita, M., Kim, K.S., Straub, C., Burlingame, A.L., Howe, J.R. & Tomita, S. (2009). A transmembrane accessory sub-unit that modulates kainate-type glutamate receptors. Neuron 61:385-396.



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