Grutzendler Lab

The overall interest  of our laboratory centers around cells in the so called  "neurovascular unit" (neurons, endothelium, astrocytes, pericytes and microglia). We aim at learning about the dynamic properties of these cells and how cell-cell interactions are disrupted in vascular and neurodegenerative pathologies. Experiments in the laboratory involve mouse models of various cerebral disorders including microvascular injury and Alzheimer's disease. The majority of projects in the laboratory are imaging-oriented. We use a variety of techniques including transcranial in vivo two photon microscopy, high-resolution confocal and electron microscopy in combination with differential fluorescent cell labeling and genetic/pharmacological manipulations.

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Jaime Grutzendler, MD
Principal Investigator